ZFIN ID: ZDB-GENE-030131-8556
Gene Name: peptidylprolyl isomerase Aa (cyclophilin A)
Gene Symbol: ppiaa    Nomenclature History

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Previous Names: ppia, fa93g09, wu:fa93g09, wu:fb05e11, wu:fb13h02, wu:fb15a05

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding; protein peptidyl-prolyl isomerization; and response to hypoxia. Predicted to localize to cytoplasm and intracellular membrane-bounded organelle. Is expressed in adipose tissue; cerebellum; digestive system; eye; and midbrain. Orthologous to human PPIA (peptidylprolyl isomerase A).
Genome Resources: Alliance (1),  Gene:336612 (1),  Ensembl(GRCz11):ENSDARG00000009212 (2)
GENE EXPRESSION
All Expression Data: 5 figures from 4 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:6901511]
  2 figures (12 images) from Rauch et al., 2003 [cegs2818]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa41288 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH ppiaa HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH ppiaa VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process protein folding (more)
    Cellular Component cytoplasm (more)
    Molecular Function isomerase activity (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ppiaa-201 (1)    Ensembl 1585
    ppiaa-202 (1)    Ensembl 722
    ncRNA ppiaa-003 (1)    Ensembl 840
    ppiaa-004 (1)    Ensembl 678
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ppiaa No data available
    MARKER RELATIONSHIPS
    ppiaa Contained in: [BAC] DKEY-231K6 (1) (order this)
    ppiaa Encodes: [EST] cegs2818 (1) (order this), fa93g09, fb05e11, fb13h02 (1), fb15a05, IMAGE:6901511 (1)
    [cDNA] MGC:110094 (1)
    ppiaa Has Artifact: [EST] zeh0294
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_212758 (1) 965 nt
    Genomic GenBank:CU137648 (1) 198585 nt
    Select Tool
    Polypeptide UniProtKB:Q7ZWJ9 (1) 190 aa
    Sequence Information (all 34)
    ORTHOLOGY for ppiaa ( Chr: 8 )
    CITATIONS (50)