ZFIN ID: ZDB-GENE-030131-8103
Gene Name: optineurin
Gene Symbol: optn
Sequence Ontology ID : SO:0000704

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Previous Names: si:ch211-240l19.3, wu:fj52f04, zgc:66386, zgc:77868

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(Including Attributions)
Location: Chr: 4 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
GENE EXPRESSION
All Expression Data: 9 figures from 3 publications
Directly Submitted Expression Data: 6 figures (11 images) from Thisse et al., 2004 [MGC:66386]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ibl51 Small Deletion Unknown Unknown CRISPR
la015529Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa143 Point Mutation Unknown Premature Stop
  • European Zebrafish Resource Center (EZRC) (order this)
  • Targeting reagents:
    PHENOTYPE
    Data: 6 figures from 2 publications
    Observed in:
    DISEASE ASSOCIATED WITH optn HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    amyotrophic lateral sclerosis type 12 Amyotrophic lateral sclerosis 12 613435
    primary open angle glaucoma Glaucoma 1, open angle, E 137760
    {Glaucoma, normal tension, susceptibility to} 606657
    DISEASE ASSOCIATED WITH optn VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process axonogenesis (more)
    Cellular Component Golgi apparatus (more)
    Molecular Function K63-linked polyubiquitin modification-dependent protein binding (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR021063 (1)
  • InterPro:IPR032419 (1)
  • InterPro:IPR032939 (1)
  • InterPro:IPR034735 (1)
  • PROSITE:PS51801 (1)
  • Pfam:PF11577 (1)
  • Pfam:PF16516 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA optn-001 (1) 2455
    optn-002 (1) 1614
    ncRNA optn-003 (1) 2212
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM optn No data available
    MARKER RELATIONSHIPS
    optnContained in: [BAC] CH211-220P15 (1) (order this), CH211-240L19 (1) (order this)
    optnEncodes: [EST] fj52f04
    [cDNA] MGC:66386 (1) (order this), MGC:77868 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001100066 (1) 2455bp
    Genomic GenBank:CR407595 (1) 206289bp Blast at MegaBLAST
    Polypeptide UniProtKB:A5WUQ0 (1) 517aa
    Sequence Clusters UniGene:79390 (1)
    Sequence Information (all 25)
    OTHER optn GENE PAGES
  • Alliance (1)
  • Gene:336159 (1)
  • VEGA:OTTDARG00000023603 (1)
  • ORTHOLOGY for optn (Chr: 4)
    CITATIONS (33)