Gene

optn

ID
ZDB-GENE-030131-8103
Name
optineurin
Symbol
optn Nomenclature History
Previous Names
  • si:ch211-240l19.3
  • wu:fj52f04
  • zgc:66386
  • zgc:77868
Type
protein_coding_gene
Location
Chr: 4 Mapping Details/Browsers
Description
Predicted to have K63-linked polyubiquitin modification-dependent protein binding activity. Involved in axonogenesis and vesicle localization. Predicted to localize to Golgi apparatus and nucleus. Human ortholog(s) of this gene implicated in Paget's disease of bone; amyotrophic lateral sclerosis (multiple); and glaucoma (multiple). Is expressed in several structures, including eye; otic vesicle; periocular mesenchyme; pleuroperitoneal region; and yolk syncytial layer. Orthologous to human OPTN (optineurin).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
12 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With optn Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
amyotrophic lateral sclerosis type 12 Alliance Amyotrophic lateral sclerosis 12 with or without frontotemporal dementia 613435
primary open angle glaucoma Alliance Glaucoma 1, open angle, E 137760
{Glaucoma, normal tension, susceptibility to} 606657
Associated With optn Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR021063 NF-kappa-B essential modulator NEMO, N-terminal
Domain IPR032419 NF-kappa-B essential modulator NEMO, CC2-LZ domain
Domain IPR034735 NEMO, Zinc finger
Domain Details Per Protein
Protein Length NEMO, Zinc finger NF-kappa-B essential modulator NEMO, CC2-LZ domain NF-kappa-B essential modulator NEMO, N-terminal
UniProtKB:A0A8M9Q5S4 519
UniProtKB:Q5RI56 517
UniProtKB:A0A8M9QAZ9 522
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab2-optn polyclonal Rabbit
  • WB
Cayman Chemical Company
4
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations