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Gene

grm1a

ID
ZDB-GENE-030131-7893
Name
glutamate receptor, metabotropic 1a
Symbol
grm1a Nomenclature History
Previous Names
  • fj39d05
  • si:ch211-51a19.1
  • wu:fj39d05
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to enable G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential; adenylate cyclase inhibiting G protein-coupled glutamate receptor activity; and neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration. Predicted to be involved in G protein-coupled glutamate receptor signaling pathway and regulation of glutamatergic synaptic transmission. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in postsynaptic density membrane. Predicted to be integral component of plasma membrane. Is expressed in brain and retinal neural layer. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 13 and spinocerebellar ataxia 44. Orthologous to human GRM1 (glutamate metabotropic receptor 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With grm1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal recessive spinocerebellar ataxia 13 Alliance Spinocerebellar ataxia, autosomal recessive 13 614831
spinocerebellar ataxia 44 Alliance Spinocerebellar ataxia 44 617691
Associated With grm1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017979 GPCR, family 3, conserved site
Domain IPR001828 Receptor, ligand binding region
Domain IPR011500 GPCR, family 3, nine cysteines domain
Domain IPR017978 GPCR family 3, C-terminal
Domain IPR019588 Metabotropic glutamate receptor, Homer-binding domain
Family IPR000162 GPCR, family 3, metabotropic glutamate receptor
Family IPR000337 GPCR, family 3
Family IPR001256 GPCR, family 3, metabotropic glutamate receptor 1
Homologous_superfamily IPR028082 Periplasmic binding protein-like I
Homologous_superfamily IPR038550 GPCR, family 3, nine cysteines domain superfamily
Domain Details Per Protein
Protein Length GPCR, family 3 GPCR, family 3, conserved site GPCR family 3, C-terminal GPCR, family 3, metabotropic glutamate receptor GPCR, family 3, metabotropic glutamate receptor 1 GPCR, family 3, nine cysteines domain GPCR, family 3, nine cysteines domain superfamily Metabotropic glutamate receptor, Homer-binding domain Periplasmic binding protein-like I Receptor, ligand binding region
UniProtKB:A0A2R9YJL7 1153
UniProtKB:A0A0R4J6Q8 1145
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations