Gene

sema3e

ID
ZDB-GENE-030131-7864
Name
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
Symbol
sema3e Nomenclature History
Previous Names
  • fj37c11
  • si:ch211-120m13.2
  • wu:fj37c11
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Exhibits neuropilin binding activity. Involved in sprouting angiogenesis. Predicted to localize to extracellular space and integral component of plasma membrane. Is expressed in several structures, including brain; cardiovascular system; endoderm; mandibular arch skeleton; and primary motor neurons. Human ortholog(s) of this gene implicated in CHARGE syndrome. Orthologous to human SEMA3E (semaphorin 3E).
Genome Resources
Note
None
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Lamont et al., 2009
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With sema3e Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
CHARGE syndrome Alliance ?CHARGE syndrome 214800
Associated With sema3e Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001627 Sema domain
Domain IPR003599 Immunoglobulin subtype
Domain IPR007110 Immunoglobulin-like domain
Domain IPR013151 Immunoglobulin
Domain IPR016201 PSI domain
Family IPR015513 Semaphorin 3E
Family IPR027231 Semaphorin
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR015943 WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
Homologous_superfamily IPR036352 Sema domain superfamily
Domain Details Per Protein
Protein Length Immunoglobulin Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold Immunoglobulin subtype PSI domain Sema domain Sema domain superfamily Semaphorin Semaphorin 3E WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:A0A2R8Q406 741
UniProtKB:A8JZV4 720
UniProtKB:Q1LYS1 768
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations