Gene

dsg2.1

ID
ZDB-GENE-030131-7531
Name
desmoglein 2, tandem duplicate 1
Symbol
dsg2.1 Nomenclature History
Previous Names
  • dsg2
  • Dsg alpha (1)
  • provisionalck738896
  • si:dkeyp-51f12.6
  • wu:fj23f02
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to have calcium ion binding activity. Involved in convergent extension involved in gastrulation; desmosome assembly; and epiboly involved in gastrulation with mouth forming second. Predicted to localize to integral component of membrane and plasma membrane. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular dysplasia 10 and dilated cardiomyopathy 1BB. Orthologous to human DSG2 (desmoglein 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Goonesinghe et al., 2012
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from Goonesinghe et al., 2012
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dsg2.1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
arrhythmogenic right ventricular dysplasia 10 Alliance Arrhythmogenic right ventricular dysplasia 10 610193
dilated cardiomyopathy 1BB Alliance Cardiomyopathy, dilated, 1BB 612877
Associated With dsg2.1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR020894 Cadherin conserved site
Domain IPR000233 Cadherin, cytoplasmic domain
Domain IPR002126 Cadherin-like
Family IPR009122 Desmosomal cadherin
Homologous_superfamily IPR015919 Cadherin-like superfamily
Homologous_superfamily IPR027397 Catenin binding domain superfamily
Domain Details Per Protein
Protein Length Cadherin conserved site Cadherin, cytoplasmic domain Cadherin-like Cadherin-like superfamily Catenin binding domain superfamily Desmosomal cadherin
UniProtKB:H2EQR6 1142
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations