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Gene

mark3a

ID
ZDB-GENE-030131-6232
Name
MAP/microtubule affinity-regulating kinase 3a
Symbol
mark3a Nomenclature History
Previous Names
  • mark3
  • fi39g08
  • wu:fi39g08
  • zgc:152848
  • zgc:55693 (1)
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to enable protein serine/threonine kinase activity and tau-protein kinase activity. Predicted to be involved in intracellular signal transduction and microtubule cytoskeleton organization. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in dendrite. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in visual impairment and progressive phthisis bulbi. Orthologous to human MARK3 (microtubule affinity regulating kinase 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mark3a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
visual impairment and progressive phthisis bulbi Alliance ?Visual impairment and progressive phthisis bulbi 618283
Associated With mark3a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR001772 Kinase associated domain 1 (KA1)
Domain IPR015940 Ubiquitin-associated domain
Family IPR033628 Serine/threonine-protein kinase MARK3
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR028375 KA1 domain/Ssp2, C-terminal
Domain Details Per Protein
Protein Length KA1 domain/Ssp2, C-terminal Kinase associated domain 1 (KA1) Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site Serine/threonine-protein kinase MARK3 Ubiquitin-associated domain
UniProtKB:Q05AN8 503
UniProtKB:F1RE94 169
UniProtKB:E9QEM6 737
UniProtKB:B8A5C0 722
UniProtKB:F1QBN0 161
UniProtKB:B8JJ31 195
UniProtKB:A0A2R8QKT7 731
UniProtKB:Q802W0 722
UniProtKB:A0A2R8QBY6 704
UniProtKB:B8JJ28 177
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations