ZFIN ID: ZDB-GENE-030131-6232
Gene Name: MAP/microtubule affinity-regulating kinase 3a
Gene Symbol: mark3a    Nomenclature History

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Previous Names: mark3, fi39g08, wu:fi39g08, zgc:152848, zgc:55693 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have protein serine/threonine kinase activity and tau-protein kinase activity. Predicted to be involved in intracellular signal transduction and microtubule cytoskeleton organization. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in visual impairment and progressive phthisis bulbi. Orthologous to human MARK3 (microtubule affinity regulating kinase 3).
Genome Resources: Alliance (1),  Gene:334300 (1),  Ensembl(GRCz11):ENSDARG00000019345 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:55693]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
PHENOTYPE No data available
DISEASE ASSOCIATED WITH mark3a HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
visual impairment and progressive phthisis bulbi Alliance ?Visual impairment and progressive phthisis bulbi 618283
DISEASE ASSOCIATED WITH mark3a VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process phosphorylation (more)
Cellular Component cytoplasm (more)
Molecular Function ATP binding (more)
GO Terms (all 12)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA mark3a-201 (1)    Ensembl 3396
mark3a-203 (1)    Ensembl 2430
mark3a-204 (1)    Ensembl 659
mark3a-205 (1)    Ensembl 974
mark3a-206 (1)    Ensembl 802
mark3a-207 (1)    Ensembl 721
ncRNA mark3a-002 (1)    Ensembl 721
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM mark3a
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(myl7:mark3a-TagRFP) myl7 mark3aTagRFP Danio rerio 1 1
MARKER RELATIONSHIPS
mark3a Contained in: [BAC] CH211-219I7 (1), RP71-84B10 (1)
mark3a Encodes: [EST] fi39g08
[cDNA] MGC:55693 (1), MGC:152848 (1), MGC:192740 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_199885 (1) 3416 nt
Genomic GenBank:BX511166 (1) 152870 nt
Select Tool
Polypeptide UniProtKB:E9QEM6 (1) 737 aa
Sequence Information (all 43)
ORTHOLOGY for mark3a ( Chr: 13 )
CITATIONS (24)