ZFIN ID: ZDB-GENE-030131-6205
Gene Name: plastin 1 (I isoform)
Gene Symbol: pls1    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: wu:fi38g03, zgc:63494

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to have actin filament binding activity. Predicted to be involved in actin filament bundle assembly and actin filament network formation. Predicted to localize to actin filament; actin filament bundle; and cytoplasm. Is expressed in macrophage; otic vesicle; pronephros; sensory system; and solid lens vesicle. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness. Orthologous to human PLS1 (plastin 1).
Genome Resources: Alliance (1),  Gene:334273 (1),  Ensembl(GRCz11):ENSDARG00000039272 (2)
GENE EXPRESSION
All Expression Data: 9 figures from 2 publications
Directly Submitted Expression Data: 7 figures (10 images) from Thisse et al., 2004 [MGC:63494]
Wild-type Stages, Structures: Segmentation:14-19 somites (16.0h-19.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
PHENOTYPE No data available
DISEASE ASSOCIATED WITH pls1 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Deafness, autosomal dominant 76 618787
DISEASE ASSOCIATED WITH pls1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process actin filament bundle assembly (more)
Cellular Component actin filament (more)
Molecular Function actin binding (more)
GO Terms (all 8)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA pls1-202 (1)    Ensembl 3185
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM pls1 No data available
MARKER RELATIONSHIPS
pls1 Contained in: [BAC] CH211-126P4 (1)
pls1 Contains: [SNP] rs3727590 (1), rs3727591 (1), rs3727592 (1)
pls1 Encodes: [EST] fi38g03
[cDNA] MGC:63494 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_199881 (1) 3142 nt
Genomic GenBank:BX248229 (1) 180233 nt
Select Tool
Polypeptide UniProtKB:F1QCE2 (1) 665 aa
Sequence Information (all 18)
ORTHOLOGY for pls1 ( Chr: 2 )
CITATIONS (27)