ZFIN ID: ZDB-GENE-041010-68
Gene Name: beta-secretase 2
Gene Symbol: bace2    Nomenclature History

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Previous Names: bace2l, zbace (1), fi26d02, wu:fi26d02, zgc:103530

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Predicted to have aspartic-type endopeptidase activity. Involved in melanocyte migration. Predicted to localize to endosome; membrane; and trans-Golgi network. Is expressed in neural crest; optic vesicle; pigment cell; polster; and retina. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human BACE2 (beta-secretase 2).
Genome Resources: Alliance (1),  Gene:449818 (1),  Ensembl(GRCz11):ENSDARG00000044781 (2)
GENE EXPRESSION
All Expression Data: 8 figures from 3 publications
Directly Submitted Expression Data: 6 figures (9 images) from Thisse et al., 2004 [IMAGE:7142521]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Larval:Day 6 (144.0h-168.0h)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu3332 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12389 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-bace2 N/A 1
    DISEASE ASSOCIATED WITH bace2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH bace2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process melanocyte migration (more)
    Cellular Component endoplasmic reticulum (more)
    Molecular Function aspartic-type endopeptidase activity (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA bace2-202 (1)    Ensembl 771
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM bace2
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(Tru.Dct:bace2,cryaa:YFP) cryaa bace2YFP Danio rerioTakifugu rubripes 1 1
    MARKER RELATIONSHIPS
    bace2 Contained in: [Fosmid] CH1073-471P3 (1)
    bace2 Encodes: [EST] fi26d02, IMAGE:7142521 (1)
    [cDNA] MGC:103530 (1), MGC:191381 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001005991 (1) 1408 nt
    Genomic GenBank:CABZ01057324 (1) 50531 nt
    Select Tool
    Polypeptide UniProtKB:X4Z0F5 (1) 462 aa
    Sequence Information (all 29)
    ORTHOLOGY for bace2 ( Chr: 15 )
    CITATIONS (29)