ZFIN ID: ZDB-GENE-030131-5767
Gene Name: P450 (cytochrome) oxidoreductase b
Gene Symbol: porb    Nomenclature History

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Previous Names: fb60a10, fi17c02, im:7051962, wu:fb60a10, wu:fi17c02, zgc:63480

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Predicted to have FMN binding activity; NADPH-hemoprotein reductase activity; and flavin adenine dinucleotide binding activity. Predicted to be involved in response to hormone. Predicted to localize to the cytosol. Human ortholog(s) of this gene implicated in Antley-Bixler syndrome and congenital adrenal hyperplasia. Orthologous to human POR (cytochrome p450 oxidoreductase).
Genome Resources: Alliance (1),  Gene:327556 (1),  Ensembl(GRCz11):ENSDARG00000059035 (2)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la027603Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39022 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH porb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Antley-Bixler syndrome Alliance Antley-Bixler syndrome with genital anomalies and disordered steroidogenesis 201750
    Disordered steroidogenesis due to cytochrome P450 oxidoreductase 613571
    DISEASE ASSOCIATED WITH porb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process oxidation-reduction process (more)
    Cellular Component endoplasmic reticulum (more)
    Molecular Function FMN binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR001094 Flavodoxin-like
    Domain IPR001433 Oxidoreductase FAD/NAD(P)-binding
    Domain IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase
    Domain IPR003097 Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding
    Domain IPR008254 Flavodoxin/nitric oxide synthase
    Domain IPR017927 FAD-binding domain, ferredoxin reductase-type
    Homologous_superfamily IPR017938 Riboflavin synthase-like beta-barrel
    Homologous_superfamily IPR023173 NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily
    Family IPR023208 NADPH-cytochrome P450 reductase
    Homologous_superfamily IPR029039 Flavoprotein-like superfamily
    Homologous_superfamily IPR039261 Ferredoxin-NADP reductase (FNR), nucleotide-binding domain
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA porb-202 (1)    Ensembl 3439
    ncRNA porb-002 (1)    Ensembl 2112
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM porb No data available
    MARKER RELATIONSHIPS
    porb Contained in: [Fosmid] CH1073-329J14 (1), CH1073-356L9 (1)
    porb Contains: [SNP] rs3728685 (1), rs3728686 (1)
    porb Encodes: [EST] fb60a10, fi17c02, IMAGE:7051962
    [cDNA] MGC:63480 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_199826 (1) 2112 bp
    Genomic GenBank:CU638704 (1) 37334 bp
    Select Tool
    Polypeptide UniProtKB:F8W4Z6 (1) 671 aa
    Sequence Information (all 19)
    ORTHOLOGY for porb ( Chr: 15 )
    CITATIONS (27)