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ZIRC
ZFIN ID: ZDB-GENE-030131-5408
Gene Name: valosin containing protein
Gene Symbol: vcp    Nomenclature History

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Previous Names: CDC48 (1), wu:fd16d05, wu:fj63d11

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have ATPase activity and polyubiquitin modification-dependent protein binding activity. Involved in chordate embryonic development; locomotory behavior; and regulation of cellular catabolic process. Predicted to localize to several cellular components, including the VCP-NPL4-UFD1 AAA ATPase complex; cytosol; and site of double-strand break. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2Y; Paget's disease of bone; amyotrophic lateral sclerosis type 14; inclusion body myopathy with Paget disease of bone and frontotemporal dementia; and inclusion body myositis. Is expressed in brain; lens; liver; and trunk musculature. Orthologous to human VCP (valosin containing protein).
Genome Resources: Alliance (1),  Gene:327197 (1),  Ensembl(GRCz11):ENSDARG00000020008 (1)
GENE EXPRESSION
All Expression Data: 6 figures from 6 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:56043]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la015693Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-vcp
    1
    MO1-vcp N/A 1
    MO2-vcp N/A 1
    MO3-vcp N/A 2
    MO4-vcp N/A 1
    DISEASE ASSOCIATED WITH vcp HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    amyotrophic lateral sclerosis type 14 Alliance Amyotrophic lateral sclerosis 14, with or without frontotemporal dementia 613954
    Charcot-Marie-Tooth disease type 2Y Alliance Charcot-Marie-Tooth disease, type 2Y 616687
    inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1 Alliance Inclusion body myopathy with early-onset Paget disease and frontotemporal dementia 1 167320
    DISEASE ASSOCIATED WITH vcp VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process chordate embryonic development (more)
    Cellular Component cytoplasm (more)
    Molecular Function ATPase activity (more)
    GO Terms (all 31)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA vcp-201 (1)    Ensembl 3041
    ncRNA vcp-004 (1) 594
    vcp-006 (1) 418
    vcp-007 (1) 686
    vcp-008 (1) 671
    vcp-009 (1) 703
    vcp-010 (1) 697
    vcp-011 (1) 598
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-vcp polyclonal IgG Rabbit Novus Biologicals, LLC
    2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM vcp No data available
    MARKER RELATIONSHIPS
    vcp Contained in: [BAC] CH211-113N10 (1) (order this)
    vcp Contains: [SNP] rs3727892 (1), rs3727893 (1), rs3727894 (1), rs3727895 (1), rs3727896 (1)
    vcp Encodes: [EST] fd16d05, fj63d11
    [cDNA] MGC:56043 (1) (order this), MGC:77072 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_201481 (1) 2659 bp
    Genomic GenBank:CR318632 (1) 143278 bp
    Select Tool
    Polypeptide UniProtKB:A0A2R8QNF0 (1) 806 aa
    Sequence Clusters UniGene:75122 (1)
    Sequence Information (all 22)
    ORTHOLOGY for vcp ( Chr: 5 )
    CITATIONS (40)