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Gene

vcp

ID
ZDB-GENE-030131-5408
Name
valosin containing protein
Symbol
vcp Nomenclature History
Previous Names
  • CDC48 (1)
  • wu:fd16d05
  • wu:fj63d11
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to enable ATP hydrolysis activity and polyubiquitin modification-dependent protein binding activity. Acts upstream of or within chordate embryonic development; locomotory behavior; and regulation of cellular catabolic process. Predicted to be located in cytoplasm and site of double-strand break. Predicted to be part of VCP-NPL4-UFD1 AAA ATPase complex. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including brain; digestive system; eye; fin bud; and trunk musculature. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2Y; Paget's disease of bone; amyotrophic lateral sclerosis type 14; inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1; and inclusion body myositis. Orthologous to human VCP (valosin containing protein).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
12 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
10 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With vcp Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
amyotrophic lateral sclerosis type 14 Alliance Frontotemporal dementia and/or amyotrophic lateral sclerosis 6 613954
Charcot-Marie-Tooth disease type 2Y Alliance Charcot-Marie-Tooth disease, type 2Y 616687
inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1 Alliance Inclusion body myopathy with early-onset Paget disease and frontotemporal dementia 1 167320
Associated With vcp Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR003960 ATPase, AAA-type, conserved site
Domain IPR003338 CDC48, N-terminal subdomain
Domain IPR003593 AAA+ ATPase domain
Domain IPR003959 ATPase, AAA-type, core
Domain IPR004201 CDC48, domain 2
Domain IPR015415 Vps4 oligomerisation, C-terminal
Domain IPR041569 AAA ATPase, AAA+ lid domain
Family IPR005938 AAA ATPase, CDC48 family
Homologous_superfamily IPR009010 Aspartate decarboxylase-like domain superfamily
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR029067 CDC48 domain 2-like superfamily
Domain Details Per Protein
Protein Length AAA ATPase, AAA+ lid domain AAA ATPase, CDC48 family AAA+ ATPase domain Aspartate decarboxylase-like domain superfamily ATPase, AAA-type, conserved site ATPase, AAA-type, core CDC48, domain 2 CDC48 domain 2-like superfamily CDC48, N-terminal subdomain P-loop containing nucleoside triphosphate hydrolase Vps4 oligomerisation, C-terminal
UniProtKB:Q7ZU99 806
UniProtKB:A0A2R8QNF0 806
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-vcp polyclonal IgG Rabbit
Novus Biologicals, LLC
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations