Gene
vcp
- ID
- ZDB-GENE-030131-5408
- Name
- valosin containing protein
- Symbol
- vcp Nomenclature History
- Previous Names
-
- CDC48 (1)
- wu:fd16d05
- wu:fj63d11
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable ATP hydrolysis activity and polyubiquitin modification-dependent protein binding activity. Acts upstream of or within chordate embryonic development; locomotory behavior; and regulation of cellular catabolic process. Predicted to be located in cytoplasm and site of double-strand break. Predicted to be part of VCP-NPL4-UFD1 AAA ATPase complex. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including brain; digestive system; eye; fin bud; and trunk musculature. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2Y; Paget's disease of bone; amyotrophic lateral sclerosis type 14; inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1; and inclusion body myositis. Orthologous to human VCP (valosin containing protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56043 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| amyotrophic lateral sclerosis type 14 | Alliance | Frontotemporal dementia and/or amyotrophic lateral sclerosis 6 | 613954 |
| Charcot-Marie-Tooth disease type 2Y | Alliance | Charcot-Marie-Tooth disease, type 2Y | 616687 |
| inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1 | Alliance | Inclusion body myopathy with early-onset Paget disease and frontotemporal dementia 1 | 167320 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR003960 | ATPase, AAA-type, conserved site |
| Domain | IPR003338 | CDC48, N-terminal subdomain |
| Domain | IPR003593 | AAA+ ATPase domain |
| Domain | IPR003959 | ATPase, AAA-type, core |
| Domain | IPR004201 | CDC48, domain 2 |
| Domain | IPR015415 | Vps4 oligomerisation, C-terminal |
| Domain | IPR041569 | AAA ATPase, AAA+ lid domain |
| Family | IPR005938 | AAA ATPase, CDC48 family |
| Homologous_superfamily | IPR009010 | Aspartate decarboxylase-like domain superfamily |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR029067 | CDC48 domain 2-like superfamily |
Domain Details Per Protein
| Protein | Length | AAA ATPase, AAA+ lid domain | AAA ATPase, CDC48 family | AAA+ ATPase domain | Aspartate decarboxylase-like domain superfamily | ATPase, AAA-type, conserved site | ATPase, AAA-type, core | CDC48, domain 2 | CDC48 domain 2-like superfamily | CDC48, N-terminal subdomain | P-loop containing nucleoside triphosphate hydrolase | Vps4 oligomerisation, C-terminal |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q7ZU99
|
806 | |||||||||||
|
UniProtKB:A0A2R8QNF0
|
806 |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-vcp | polyclonal | IgG | Rabbit |
|
Novus Biologicals, LLC
|
2 |
Plasmids
No data available