| ZFIN ID: ZDB-GENE-030131-5408 |
| Gene Name: | valosin containing protein | |||||||||||||
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| Gene Symbol: | vcp Nomenclature History |
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| Previous Names: | CDC48 (1), wu:fd16d05, wu:fj63d11 | |||||||||||||
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| Gene Type: | protein_coding_gene | |||||||||||||
| Location: | Chr: 5 Mapping Details/Browsers | |||||||||||||
| Description: | Predicted to have ATPase activity and polyubiquitin modification-dependent protein binding activity. Involved in chordate embryonic development; locomotory behavior; and regulation of cellular catabolic process. Predicted to localize to several cellular components, including the VCP-NPL4-UFD1 AAA ATPase complex; cytosol; and site of double-strand break. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2Y; Paget's disease of bone; amyotrophic lateral sclerosis type 14; inclusion body myopathy with Paget disease of bone and frontotemporal dementia; and inclusion body myositis. Is expressed in brain; lens; liver; and trunk musculature. Orthologous to human VCP (valosin containing protein). | |||||||||||||
| Genome Resources: | Alliance (1), Gene:327197 (1), Ensembl(GRCz11):ENSDARG00000020008 (1) | |||||||||||||
| All Expression Data: | 6 figures from 6 publications |
| Directly Submitted Expression Data: | 1 figure (1 image) from Thisse et al., 2004 [MGC:56043] |
| Wild-type Stages, Structures: | Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult) |
| Curated Microarray Expression: | GEO (1) |
| Allele | Type | Localization | Consequence | Mutagen | Suppliers |
|---|---|---|---|---|---|
| la015693Tg | Transgenic Insertion | Unknown | Unknown | DNA |
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| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| amyotrophic lateral sclerosis type 14 | Alliance | Amyotrophic lateral sclerosis 14, with or without frontotemporal dementia | 613954 |
| Charcot-Marie-Tooth disease type 2Y | Alliance | Charcot-Marie-Tooth disease, type 2Y | 616687 |
| inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1 | Alliance | Inclusion body myopathy with early-onset Paget disease and frontotemporal dementia 1 | 167320 |
| Ontology | GO Term |
|---|---|
| Biological Process | chordate embryonic development (more) |
| Cellular Component | cytoplasm (more) |
| Molecular Function | ATPase activity (more) |
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| Type | Name | Length (nt) | Analysis | |
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| mRNA |
vcp-201
(1)
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3041 |
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| ncRNA | vcp-004 (1) | 594 |
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| vcp-006 (1) | 418 |
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| vcp-007 (1) | 686 |
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| vcp-008 (1) | 671 |
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| vcp-009 (1) | 703 |
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| vcp-010 (1) | 697 |
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| vcp-011 (1) | 598 |
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| Browsers: UCSC, NCBI, Ensembl, ZFIN |
| Name | Type | Isotype | Host Organism | Assay | Source | Publications |
|---|---|---|---|---|---|---|
| Ab1-vcp | polyclonal | IgG | Rabbit |
Novus Biologicals, LLC
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2 |
| vcp Contained in: | [BAC] CH211-113N10 (1) (order this) |
| vcp Contains: | [SNP] rs3727892 (1), rs3727893 (1), rs3727894 (1), rs3727895 (1), rs3727896 (1) |
| vcp Encodes: |
[EST]
fd16d05,
fj63d11
[cDNA] MGC:56043 (1) (order this), MGC:77072 (1) (order this) |
| Type | Accession # | Length (bp/aa) | Analysis |
|---|---|---|---|
| RNA | RefSeq:NM_201481 (1) | 2659 bp |
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| Genomic | GenBank:CR318632 (1) | 143278 bp | |
| Polypeptide | UniProtKB:A0A2R8QNF0 (1) | 806 aa |
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| Sequence Clusters | UniGene:75122 (1) |
