ZFIN ID: ZDB-GENE-030131-3143
Gene Name: apolipoprotein A-IV b, tandem duplicate 2
Gene Symbol: apoa4b.2    Nomenclature History

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Previous Names: fc28d04, wu:fc10a03, wu:fc28d04 (1), zgc:194131

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Predicted to have several functions, including cholesterol binding activity; cholesterol transfer activity; and phosphatidylcholine-sterol O-acyltransferase activator activity. Predicted to be involved in several processes, including lipid homeostasis; lipid transport; and plasma lipoprotein particle organization. Predicted to localize to the chylomicron and high-density lipoprotein particle. Human ortholog(s) of this gene implicated in Alzheimer's disease; colitis; myocardial infarction; and ulcerative colitis. Is expressed in ball; extension; intestine; yolk; and yolk syncytial layer. Orthologous to human APOA4 (apolipoprotein A4).
Genome Resources: Alliance (1),  Gene:570354 (1), 
GENE EXPRESSION
All Expression Data: 16 figures from 3 publications
Directly Submitted Expression Data: 12 figures (17 images) from Rauch et al., 2003 [fc28d04]
Wild-type Stages, Structures: Gastrula:Bud (10.0h-10.33h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa22836 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa22837 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH apoa4b.2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH apoa4b.2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process lipid transport (more)
    Cellular Component extracellular region (more)
    Molecular Function lipid binding (more)
    GO Terms (all 4)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR000074 Apolipoprotein A/E
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA apoa4b.2-201 (1)    Ensembl 970
    apoa4b.2-202 (1)    Ensembl 811
    apoa4b.2-203 (1)    Ensembl 1046
    apoa4b.2-204 (1)    Ensembl 588
    ncRNA apoa4b.2-002 (1)    Ensembl 617
    Browsers: NCBI
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM apoa4b.2 No data available
    MARKER RELATIONSHIPS
    apoa4b.2 Contained in: [BAC] DKEY-7F3 (1) (order this)
    apoa4b.2 Encodes: [EST] fc10a03, fc28d04 (order this)
    [cDNA] MGC:194131 (1), MGC:194132 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001128758 (1) 947 bp
    Genomic GenBank:BX004983 (1) 234489 bp Blast at MegaBLAST
    Polypeptide UniProtKB:B3DHC5 (1) 255 aa
    Sequence Information (all 22)
    ORTHOLOGY for apoa4b.2 ( Chr: 16 )
    CITATIONS (30)