ZFIN ID: ZDB-GENE-030131-2935
Gene Name: insulin-like growth factor 2b
Gene Symbol: igf2b    Nomenclature History

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Previous Names: igf2a (1), fc21h08, wu:fc21h08 (1), wu:fc34h12 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Exhibits insulin-like growth factor receptor binding activity. Involved in animal organ development; fin regeneration; and somitogenesis. Predicted to localize to extracellular space. Is expressed in several structures, including central nervous system; digestive system; hypochord; pericardial region; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Silver-Russell syndrome; choriocarcinoma; hepatocellular carcinoma; and rheumatoid arthritis. Orthologous to human IGF2 (insulin like growth factor 2).
Genome Resources: Alliance (1),  Gene:324215 (1),  Ensembl(GRCz11):ENSDARG00000033307 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb170 Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • ihb171 Insertion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • sa32534 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-igf2b 1
    MO1-igf2b N/A 1
    MO2-igf2b N/A 2
    MO3-igf2b N/A 2
    MO4-igf2b N/A 1
    DISEASE ASSOCIATED WITH igf2b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Silver-Russell syndrome 3 616489
    DISEASE ASSOCIATED WITH igf2b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process notochord development (more)
    Cellular Component extracellular region (more)
    Molecular Function insulin-like growth factor receptor binding (more)
    GO Terms (all 20)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA igf2b-201 (1)    Ensembl 3385
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM igf2b No data available
    MARKER RELATIONSHIPS
    igf2b Contained in: [BAC] CH211-220G18, DKEY-217J16 (order this)
    igf2b Encodes: [EST] fc21h08, fc34h12 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001001815 (1) 3391 nt
    Genomic GenBank:AL954320 (1) 215130 nt Blast at MegaBLAST
    Polypeptide UniProtKB:Q8JIE4 (1) 212 aa
    Sequence Information (all 11)
    ORTHOLOGY for igf2b ( Chr: 25 )
    CITATIONS (87)