ZFIN ID: ZDB-GENE-030131-2168
Gene Name: apolipoprotein C-II
Gene Symbol: apoc2    Nomenclature History

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Previous Names: fb71a04, fb98g08, wu:fb52e03, wu:fb71a04, wu:fb98g08

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Predicted to have enzyme activator activity. Involved in definitive hemopoiesis and lipoprotein catabolic process. Predicted to localize to chylomicron. Is expressed in intestine; liver; pancreas; and yolk. Used to study familial hyperlipidemia; familial lipoprotein lipase deficiency; and hyperlipoproteinemia type IV. Human ortholog(s) of this gene implicated in familial apolipoprotein C-II deficiency; familial hyperlipidemia; and multiple sclerosis. Orthologous to human APOC2 (apolipoprotein C2).
Genome Resources: Alliance (1),  Gene:568972 (1),  Ensembl(GRCz11):ENSDARG00000092155 (2)
GENE EXPRESSION
All Expression Data: 4 figures from 2 publications
Wild-type Stages, Structures: Hatching:Long-pec (48.0h-60.0h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sd38 Indel Exon 3 Frameshift TALEN
sd39 Indel Exon 3 Premature Stop TALEN
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-apoc2
2
MO1-apoc2 N/A 2
TALEN1-apoc2 1
DISEASE ASSOCIATED WITH apoc2 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
familial apolipoprotein C-II deficiency Alliance Hyperlipoproteinemia, type Ib 207750
GENE ONTOLOGY
Ontology GO Term
Biological Process lipoprotein catabolic process (more)
Cellular Component chylomicron (more)
Molecular Function enzyme activator activity (more)
GO Terms (all 6)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA apoc2-202 (1)    Ensembl 798
ncRNA apoc2-002 (1)    Ensembl 534
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM apoc2 No data available
MARKER RELATIONSHIPS
apoc2 Contained in: [BAC] DKEY-7F3 (order this)
apoc2 Encodes: [EST] fb52e03, fb71a04, fb98g08
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001326448 (1)
Genomic GenBank:BX004983 (1) 234489 nt Blast at MegaBLAST
Polypeptide UniProtKB:A0A286YAE3 (1) 114 aa
Sequence Information (all 19)
ORTHOLOGY for apoc2 ( Chr: 16 )
CITATIONS (29)