ZFIN ID: ZDB-GENE-030131-215
Gene Name: cofilin 1
Gene Symbol: cfl1    Nomenclature History

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Previous Names: cfl2l, wu:fb17d06, wu:fb18d11, wu:fd59f08, wu:fj34b08

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Predicted to have actin filament binding activity. Involved in several processes, including cilium assembly; determination of heart left/right asymmetry; and gastrulation. Predicted to localize to cortical actin cytoskeleton. Is expressed in several structures, including DEL; blastomere; digestive system; nervous system; and renal system. Orthologous to human CFL1 (cofilin 1).
Genome Resources: Alliance (1),  Gene:321496 (1),  Ensembl(GRCz11):ENSDARG00000021124 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hi3736aTg Transgenic Insertion Intron 1 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-cfl1 N/A 1
    MO2-cfl1 N/A 2
    MO3-cfl1 N/A 2
    DISEASE ASSOCIATED WITH cfl1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH cfl1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cilium assembly (more)
    Cellular Component actin cytoskeleton (more)
    Molecular Function actin binding (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cfl1-201 (1)    Ensembl 1713
    ncRNA cfl1-002 (1)    Ensembl 471
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-cfl polyclonal Goat WB Thermo Scientific Pierce Protein Research Products
    2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cfl1 No data available
    MARKER RELATIONSHIPS
    cfl1 Contained in: [BAC] CH211-126C2 (1)
    cfl1 Encodes: [EST] fb17d06 (order this), fb18d11, fd59f08 (1), fj34b08 (1)
    cfl1 Has Artifact: [cDNA] MGC:103610 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_213641 (1) 1423 nt
    Genomic GenBank:CT573152 (1) 134793 nt
    Select Tool
    Polypeptide UniProtKB:Q6TH32 (1) 165 aa
    Sequence Information (all 17)
    ORTHOLOGY for cfl1 ( Chr: 14 )
    CITATIONS (43)