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Gene

agt

ID
ZDB-GENE-030131-1205
Name
angiotensinogen
Symbol
agt Nomenclature History
Previous Names
  • wu:fb62f06
  • wu:fj87b02
  • zgc:111892
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity and regulation of apoptotic process. Predicted to act upstream of or within regulation of systemic arterial blood pressure by renin-angiotensin and vasoconstriction. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in liver. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Henoch-Schoenlein purpura; artery disease (multiple); heart conduction disease (multiple); and hydronephrosis. Orthologous to human AGT (angiotensinogen).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With agt Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
essential hypertension Alliance {Hypertension, essential, susceptibility to} 145500
Renal tubular dysgenesis 267430
{Preeclampsia, susceptibility to}
Associated With agt Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR023795 Serpin, conserved site
Domain IPR023796 Serpin domain
Domain IPR033834 Angiotensinogen, serpin domain
Family IPR000215 Serpin family
Family IPR000227 Angiotensinogen
Homologous_superfamily IPR036186 Serpin superfamily
Homologous_superfamily IPR042178 Serpin superfamily, domain 1
Homologous_superfamily IPR042185 Serpin superfamily, domain 2
Domain Details Per Protein
Protein Length Angiotensinogen Angiotensinogen, serpin domain Serpin, conserved site Serpin domain Serpin family Serpin superfamily Serpin superfamily, domain 1 Serpin superfamily, domain 2
UniProtKB:Q8JH29 454
UniProtKB:Q502R9 454
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations