Gene

agt

ID

ZDB-GENE-030131-1205

Name

angiotensinogen

Symbol

agt Nomenclature History

Previous Names

wu:fb62f06
wu:fj87b02
zgc:111892

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in regulation of apoptotic process. Predicted to act upstream of or within regulation of systemic arterial blood pressure by renin-angiotensin and vasoconstriction. Predicted to be active in extracellular space. Is expressed in liver. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Henoch-Schoenlein purpura; artery disease (multiple); heart conduction disease (multiple); and hydronephrosis. Orthologous to human AGT (angiotensinogen).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With agt Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
essential hypertension	Alliance	{Hypertension, essential, susceptibility to}	145500
		Renal tubular dysgenesis	267430
		{Preeclampsia, susceptibility to}

Associated With agt Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR023795	Serpin, conserved site
Domain	IPR023796	Serpin domain
Domain	IPR033834	Angiotensinogen, serpin domain
Family	IPR000215	Serpin family
Family	IPR000227	Angiotensinogen
Homologous_superfamily	IPR036186	Serpin superfamily
Homologous_superfamily	IPR042178	Serpin superfamily, domain 1
Homologous_superfamily	IPR042185	Serpin superfamily, domain 2