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ZIRC
ZFIN ID: ZDB-GENE-030131-1077
Gene Name: hepatocyte nuclear factor 4, alpha
Gene Symbol: hnf4a
Sequence Ontology ID : SO:0000704

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Previous Names: fb58h09, id:ibd1279, NR2A1 (1), sb:eu665, wu:fb58h09

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(Including Attributions)
Location: Chr: 23 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Exhibits DNA-binding activity transcription factor activity; involved in pancreas regeneration, response to bacterium, and type B pancreatic cell development; predicted to localize to the nucleus;  ...
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
rdu14 Small Deletion Unknown Frameshift, Premature Stop CRISPR
rdu15 Insertion Unknown Frameshift, Premature Stop CRISPR
sa43991 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents:
    PHENOTYPE
    Data: 3 figures from 2 publications
    Observed in:
    DISEASE ASSOCIATED WITH hnf4a HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    maturity-onset diabetes of the young type 1 MODY, type I 125850
    type 2 diabetes mellitus {Diabetes mellitus, noninsulin-dependent} 125853
    Fanconi renotubular syndrome 4, with maturity-onset diabetes of the young 616026
    DISEASE ASSOCIATED WITH hnf4a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process endocrine pancreas development (more)
    Cellular Component nucleus (more)
    Molecular Function DNA-binding transcription factor activity (more)
    GO Terms (all 15)
    TRANSCRIPTS
    Type Name Length (bp) Analysis
    ncRNA hnf4a-003 (1) 339
    hnf4a-004 (1) 732
    aberrant processed transcript hnf4a-202 (1) 1732
    mRNA hnf4a-204 (1) 850
    hnf4a-206 (1) 3523
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM hnf4a No data available
    MARKER RELATIONSHIPS
    hnf4aContained in: [BAC] DKEY-24L7 (1) (order this)
    hnf4aEncodes: [EST] af473824 (1) (order this), eu665 (1), fb58h09, ibd1279 (order this)
    [cDNA] MGC:66028 (1) (order this), MGC:174503 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_194368 (1) 1365bp
    Genomic GenBank:CR318614 (1) 79471bp
    Select Tool
    Polypeptide UniProtKB:Q6PHH5 (1) 463aa
    Sequence Clusters UniGene:77049 (1)
    Sequence Information (all 36)
    ORTHOLOGY for hnf4a (Chr: 23)
    CITATIONS (68)