ZFIN ID: ZDB-GENE-030131-1077
Gene Name: hepatocyte nuclear factor 4, alpha
Gene Symbol: hnf4a    Nomenclature History

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Previous Names: fb58h09, id:ibd1279, NR2A1 (1), sb:eu665, wu:fb58h09

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Exhibits DNA-binding transcription factor activity. Involved in pancreas regeneration; response to bacterium; and type B pancreatic cell development. Predicted to localize to nucleus. Is expressed in gut; intestinal bulb primordium; liver; pleuroperitoneal region; and yolk syncytial layer. Human ortholog(s) of this gene implicated in Fanconi syndrome; familial combined hyperlipidemia; hypoglycemia; maturity-onset diabetes of the young type 1; and type 2 diabetes mellitus. Orthologous to human HNF4A (hepatocyte nuclear factor 4 alpha).
Genome Resources: Alliance (1),  Gene:322358 (1),  Ensembl(GRCz11):ENSDARG00000021494 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
rdu14 Small Deletion Unknown Frameshift, Premature Stop CRISPR
rdu15 Insertion Unknown Frameshift, Premature Stop CRISPR
sa43991 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-hnf4a 1
    CRISPR2-hnf4a 1
    CRISPR3-hnf4a 1
    MO1-hnf4a N/A 1
    MO2-hnf4a N/A 1
    PHENOTYPE
    Data: 3 figures from 2 publications
    Observed in:
    DISEASE ASSOCIATED WITH hnf4a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    maturity-onset diabetes of the young type 1 Alliance MODY, type I 125850
    type 2 diabetes mellitus Alliance {Diabetes mellitus, noninsulin-dependent} 125853
    Fanconi renotubular syndrome 4, with maturity-onset diabetes of the young 616026
    DISEASE ASSOCIATED WITH hnf4a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process endocrine pancreas development (more)
    Cellular Component host cell nucleus (more)
    Molecular Function DNA-binding transcription factor activity (more)
    GO Terms (all 21)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    aberrant processed transcript hnf4a-202 (1)    Ensembl 1732
    mRNA hnf4a-204 (1)    Ensembl 850
    hnf4a-206 (1)    Ensembl 3523
    ncRNA hnf4a-003 (1)    Ensembl 339
    hnf4a-004 (1)    Ensembl 732
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    ab1-hnf4a polyclonal IgG Goat IHC Santa Cruz Biotechnology, Inc.
    9
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM hnf4a No data available
    MARKER RELATIONSHIPS
    hnf4a Contained in: [BAC] DKEY-24L7 (1) (order this)
    hnf4a Encodes: [EST] af473824 (1), eu665 (1), fb58h09, ibd1279
    [cDNA] MGC:66028 (1), MGC:174503 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_194368 (1) 1365 nt
    Genomic GenBank:CR318614 (1) 79471 nt
    Select Tool
    Polypeptide UniProtKB:Q6PHH5 (1) 463 aa
    Sequence Information (all 35)
    ORTHOLOGY for hnf4a ( Chr: 23 )
    CITATIONS (74)