Gene

hnf4a

ID
ZDB-GENE-030131-1077
Name
hepatocyte nuclear factor 4, alpha
Symbol
hnf4a Nomenclature History
Previous Names
  • fb58h09
  • id:ibd1279
  • NR2A1 (1)
  • sb:eu665
  • wu:fb58h09
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Exhibits DNA-binding transcription factor activity. Involved in pancreas regeneration; response to bacterium; and type B pancreatic cell development. Predicted to localize to nuclear chromatin. Is expressed in gut; intestinal bulb primordium; liver; pleuroperitoneal region; and yolk syncytial layer. Human ortholog(s) of this gene implicated in Fanconi renotubular syndrome 4; familial combined hyperlipidemia; hypoglycemia; maturity-onset diabetes of the young type 1; and type 2 diabetes mellitus. Orthologous to human HNF4A (hepatocyte nuclear factor 4 alpha).
Genome Resources
Note
None
Expression
All Expression Data
48 figures from 23 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With hnf4a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Fanconi renotubular syndrome 4 Alliance Fanconi renotubular syndrome 4, with maturity-onset diabetes of the young 616026
maturity-onset diabetes of the young type 1 Alliance MODY, type I 125850
type 2 diabetes mellitus Alliance {Diabetes mellitus, noninsulin-dependent} 125853
Associated With hnf4a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000536 Nuclear hormone receptor, ligand-binding domain
Domain IPR001628 Zinc finger, nuclear hormone receptor-type
Family IPR001723 Nuclear hormone receptor
Family IPR039067 Hepatocyte nuclear factor 4-alpha
Homologous_superfamily IPR013088 Zinc finger, NHR/GATA-type
Homologous_superfamily IPR035500 Nuclear hormone receptor-like domain superfamily
Domain Details Per Protein
Protein Length Hepatocyte nuclear factor 4-alpha Nuclear hormone receptor Nuclear hormone receptor, ligand-binding domain Nuclear hormone receptor-like domain superfamily Zinc finger, NHR/GATA-type Zinc finger, nuclear hormone receptor-type
UniProtKB:E9QGV6 42
UniProtKB:E9QFX6 274
UniProtKB:Q6PHH5 463
UniProtKB:A8E5K2 427
UniProtKB:Q8AXB6 454
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
ab1-hnf4a polyclonal IgG Goat
  • IHC
Santa Cruz Biotechnology, Inc.
9
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations