ZFIN ID: ZDB-GENE-030131-102
Gene Name: cellular communication network factor 2a
Gene Symbol: ccn2a    Nomenclature History

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Previous Names: ctgf, ctgfa, hm:zeh1559, si:dkey-266k12.4, wu:fl25c03 (1), zCTGF-c20 (1), zgc:136644

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have heparin binding activity and integrin binding activity. Involved in several processes, including definitive hemopoiesis; endoderm development; and notochord development. Predicted to localize to extracellular matrix. Is expressed in several structures, including digestive system; fin; head; mesoderm; and spinal cord. Orthologous to human CCN2 (cellular communication network factor 2).
Genome Resources: Alliance (1),  Gene:321449 (1),  Ensembl(GRCz11):ENSDARG00000042934 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
bns50 Small Deletion Exon 3 Frameshift, Premature Stop TALEN
el654 Small Deletion Unknown Frameshift CRISPR
sa11839 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13699 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa25135 Point Mutation Unknown Premature Stop ENU
    zf3090 Small Deletion Unknown Unknown CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-ccn2a
    3
    CRISPR2-ccn2a
    1
    CRISPR3-ccn2a
    1
    CRISPR4-ccn2a
    1
    CRISPR5-ccn2a
    1
    CRISPR6-ccn2a
    1
    CRISPR7-ccn2a
    1
    CRISPR8-ccn2a 1
    MO1-ccn2a N/A 1
    MO2-ccn2a N/A 1
    MO3-ccn2a N/A 3
    TALEN1-ccn2a 1
    DISEASE ASSOCIATED WITH ccn2a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH ccn2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process chordate embryonic development (more)
    Cellular Component extracellular region (more)
    Molecular Function insulin-like growth factor binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ctgfa-201 (1)    Ensembl 2119
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ccn2a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-1ccn2a:d2GFP) ccn2a GFP Danio rerio 1 1
    Tg(ccn2a:EGFP) ccn2a EGFP Danio rerio 1 2
    Tg(hsp70l:ccn2a-2A-EGFP) hsp70l 2Accn2aEGFP Danio rerio 1 2
    tg(uas:ccn2a-egfp) UAS ccn2aEGFP Danio rerio 1 1
    Tg2(ccn2a:EGFP) ccn2a EGFP Danio rerio 1 1
    Tg2(hsp70l:ccn2a-2A-EGFP) hsp70l 2Accn2aEGFP Danio rerio 1 1
    Tg3(hsp70l:ccn2a-2A-EGFP) hsp70l 2Accn2aEGFP Danio rerio 1 1
    MARKER RELATIONSHIPS
    ccn2a Contained in: [BAC] DKEY-266K12 (1) (order this)
    ccn2a Encodes: [EST] cegs2096 (1) (order this), eu936 (1), fl25c03, zeh1559 (1)
    [cDNA] MGC:136644 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001015041 (1) 2119 nt
    Genomic GenBank:BX323010 (1) 176396 nt
    Select Tool
    Polypeptide UniProtKB:Q5RI33 (1) 345 aa
    Sequence Information (all 30)
    ORTHOLOGY for ccn2a ( Chr: 20 )
    CITATIONS (73)