ZFIN ID: ZDB-GENE-020419-24
Gene Name: minichromosome maintenance complex component 2
Gene Symbol: mcm2    Nomenclature History

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Previous Names: cb737 (1), chunp6905, MCM2 minichromosome maintenance deficient 2

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Exhibits chromatin binding activity. Predicted to contribute to 3'-5' DNA helicase activity. Involved in regulation of cilium assembly; retina development in camera-type eye; and thymus development. Predicted to localize to MCM complex and nucleus. Is expressed in several structures, including hindbrain neural rod; midbrain neural rod; optic vesicle; paraxial mesoderm; and thymus. Human ortholog(s) of this gene implicated in Alzheimer's disease and autosomal dominant nonsyndromic deafness 70. Orthologous to human MCM2 (minichromosome maintenance complex component 2).
Genome Resources: Alliance (1),  Gene:192338 (1),  Ensembl(GRCz11):ENSDARG00000102798 (1)
GENE EXPRESSION
All Expression Data: 11 figures from 5 publications
Directly Submitted Expression Data: 6 figures (14 images) from Thisse et al., 2001 [cb737]
Wild-type Stages, Structures: Cleavage:64-cell (2.0h-2.25h) to Larval:Day 4 (96.0h-120.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hi1244Tg Transgenic Insertion Intron 1 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • hi3205Tg Transgenic Insertion Intron 1 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38175 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38176 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-mcm2 N/A 1
    MO2-mcm2 N/A 1
    MO3-mcm2 N/A 1
    MO4-mcm2 N/A 1
    DISEASE ASSOCIATED WITH mcm2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal dominant nonsyndromic deafness 70 Alliance ?Deafness, autosomal dominant 70 616968
    DISEASE ASSOCIATED WITH mcm2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of cilium assembly (more)
    Cellular Component MCM complex (more)
    Molecular Function chromatin binding (more)
    GO Terms (all 22)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-mcm2 polyclonal IgG1 Rabbit WB BD Biosciences
    2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mcm2 No data available
    MARKER RELATIONSHIPS
    mcm2 Encodes: [EST] cb737 (1) (order this)
    [cDNA] MGC:55282 (1), MGC:77255 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_173257 (1)
    Polypeptide UniProtKB:A0A0R4IF65 (1) 889 aa
    Sequence Information (all 18)
    ORTHOLOGY for mcm2 ( Chr: 22 )
    CITATIONS (43)