ZFIN ID: ZDB-GENE-011212-5
Gene Name: phosphoribosyl pyrophosphate synthetase 1A
Gene Symbol: prps1a
Previous Names: prps1, cb96 (1), wu:fa18f03, wu:fb33h12, wu:fd26g08, zgc:55299, zgc:76932
Location: Chr: 5 Details
Nomenclature History
GENE EXPRESSION
Directly Submitted Expression Data: 6 figures (15 images) from Thisse et al., 2001 [cb96]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Hatching:Long-pec (48.0h-60.0h)
  alar plate midbrain region, immature eye, midbrain, optic tectum (all 10) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Mutagen Suppliers
la015591Tg Transgenic Insertion DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents: CRISPR1-prps1a (1), CRISPR2-prps1a (2), CRISPR3-prps1a (2)
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH prps1a HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Arts syndrome Arts syndrome 301835
    Charcot-Marie-Tooth disease type X Charcot-Marie-Tooth disease, X-linked recessive, 5 311070
    X-linked nonsyndromic deafness Deafness, X-linked 1 304500
    Phosphoribosylpyrophosphate synthetase superactivity 300661
    Gout, PRPS-related 300661
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cellular biosynthetic process (more)
    Molecular Function magnesium ion binding (more)
    GO Terms (all 5)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000842 (1)
  • InterPro:IPR005946 (1)
  • InterPro:IPR029057 (1)
  • InterPro:IPR029099 (1)
  • PROSITE:PS00114 (1)
  • Pfam:PF13793 (1)
  • Pfam:PF14572 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA prps1a-001 (1) 2311
    prps1a-002 (1) 1282
    GENE PRODUCT DESCRIPTION
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM prps1a No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    prps1aContained in: [BAC] DKEY-114C15 (1) (order this)
    prps1aEncodes: [EST] cb96 (1) (order this), fa18f03, fb33h12, fd26g08
    [cDNA] MGC:55299 (order this), MGC:76932 (1) (order this), MGC:111881 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_213533 (1) 2292bp
    Genomic GenBank:BX640539 (1) 86752bp
    Select Tool
    Polypeptide UniProtKB:A0A0R4IW25 (1) 322aa
    Sequence Clusters UniGene:142104 (1)
    Sequence Information (all 36)
    OTHER prps1a GENE PAGES
  • Gene:140620 (1)
  • VEGA:OTTDARG00000018997 (1)
  • Ensembl(GRCz10):ENSDARG00000015524 (1)
  • ORTHOLOGY for prps1a (Chr: 5)
    Species Symbol Chromosome Accession # Evidence
    Human PRPS1 X
  • Gene:5631
  • OMIM:311850
  • HGNC:9462
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (22)