Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-011212-5
Gene Name: phosphoribosyl pyrophosphate synthetase 1A
Gene Symbol: prps1a
Previous Names: prps1, cb96 (1), wu:fa18f03, wu:fb33h12, wu:fd26g08, zgc:55299, zgc:76932
Nomenclature History
GENE EXPRESSION
Directly Submitted Expression Data: 6 figures (15 images) from Thisse et al., 2001 [cb96]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Hatching:Long-pec (48.0h-60.0h)
  alar plate midbrain region, immature eye, midbrain, optic tectum (all 10) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Alleles: la015591Tg
PHENOTYPE
Phenotype of Human Orthologue OMIM Phenotype ID
Arts syndrome 301835
Charcot-Marie-Tooth disease, X-linked recessive, 5 311070
Deafness, X-linked 1 304500
Gout, PRPS-related 300661
Phosphoribosylpyrophosphate synthetase superactivity 300661
GENE ONTOLOGY
Ontology GO Term
Biological Process cellular biosynthetic process (more)
Molecular Function magnesium ion binding (more)
GO Terms (all 5)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000842 (1)
  • InterPro:IPR005946 (1)
  • PROSITE:PS00114 (1)
  • Pfam:PF14572 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA prps1a-001 (1) 2311
    prps1a-002 (1) 1282
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM prps1a No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    prps1a Contained in: [BAC] DKEY-114C15 (1)
    prps1a Encodes: [EST] cb96 (1) (order this), fa18f03, fb33h12, fd26g08
    [cDNA] MGC:55299 (order this), MGC:76932 (1) (order this), MGC:111881 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_213533 (1) 2292 bp
    Genomic GenBank:BX640539 (1) 86752 bp
    Select Tool
    Polypeptide UniProtKB:Q4KME9 (1) 320 aa
    Sequence Clusters UniGene:75874 (1)
    Sequence Information (all 35)
    OTHER prps1a GENE PAGES
  • Gene:140620 (1)
  • VEGA:OTTDARG00000018997 (1)
  • Ensembl(Zv9):ENSDARG00000015524 (1)
  • MAPPING INFORMATION
    Chr: 5 Details
    ORTHOLOGY
      Evidence
    Species Symbol Chromosome (Position) Accession # AA CL
    Zebrafish prps1a 5  
    Human PRPS1 X (Xq22.3)
  • OMIM:311850
  • Gene:5631
  • CITATIONS (18)