Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-011212-5
Gene Name: phosphoribosyl pyrophosphate synthetase 1A
Gene Symbol: prps1a
Previous Names: prps1, cb96 (1), wu:fa18f03, wu:fb33h12, wu:fd26g08, zgc:55299, zgc:76932
Nomenclature History
GENE EXPRESSION
Directly Submitted Expression Data: 6 figures (15 images) from Thisse et al., 2001 [cb96]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Hatching:Long-pec (48.0h-60.0h)
  alar plate midbrain region, immature eye, midbrain, optic tectum (all 10) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Alleles: la015591Tg
PHENOTYPE
Phenotype of Human Orthologue OMIM Phenotype ID
Arts syndrome 301835
Charcot-Marie-Tooth disease, X-linked recessive, 5 311070
Deafness, X-linked 1 304500
Gout, PRPS-related 300661
Phosphoribosylpyrophosphate synthetase superactivity 300661
GENE ONTOLOGY No data available
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000842
  • InterPro:IPR005946
  • PROSITE:PS00114
  • Pfam:PF14572
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA prps1a-001 (1) 2311
    prps1a-002 (1) 1282
    GENE PRODUCT DESCRIPTION No description available
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM prps1a No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    prps1a Contained in: [BAC] DKEY-114C15 (1)
    prps1a Encodes: [EST] cb96 (1) (order this), fa18f03, fb33h12, fd26g08
    [cDNA] MGC:55299 (order this), MGC:76932 (1) (order this), MGC:111881 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_213533 (1) 2292 bp
    Genomic GenBank:BX640539 (1) 86752 bp
    Select Tool
    Polypeptide UniProtKB:Q4KME9 320 aa
    Sequence Clusters UniGene:75874 (1)
    Sequence Information (all 35)
    OTHER prps1a GENE PAGES
  • Gene:140620 (1)
  • VEGA:OTTDARG00000018997 (1)
  • Ensembl(Zv9):ENSDARG00000015524 (1)
  • MAPPING INFORMATION
    Chr: 5 Details
    ORTHOLOGY
      Evidence
    Species Symbol Chromosome (Position) Accession # AA CL
    Zebrafish prps1a 5  
    Human PRPS1 X (Xq22.3)
  • OMIM:311850
  • Gene:5631
  • CITATIONS (16)