ZFIN ID: ZDB-GENE-011212-5
Gene Name: phosphoribosyl pyrophosphate synthetase 1A
Gene Symbol: prps1a
Previous Names: prps1, cb96 (1), wu:fa18f03, wu:fb33h12, wu:fd26g08, zgc:55299, zgc:76932
Location: Chr: 5 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
Directly Submitted Expression Data: 6 figures (15 images) from Thisse et al., 2001 [cb96]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Hatching:Long-pec (48.0h-60.0h)
  alar plate midbrain region, immature eye, midbrain, optic tectum (all 10) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la015591Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents: CRISPR1-prps1a (1), CRISPR2-prps1a (2), CRISPR3-prps1a (2)
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH prps1a HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Arts syndrome Arts syndrome 301835
    Charcot-Marie-Tooth disease X-linked recessive 5 Charcot-Marie-Tooth disease, X-linked recessive, 5 311070
    X-linked nonsyndromic deafness Deafness, X-linked 1 304500
    Gout, PRPS-related 300661
    Phosphoribosylpyrophosphate synthetase superactivity 300661
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cellular biosynthetic process (more)
    Molecular Function magnesium ion binding (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000836 (1)
  • InterPro:IPR000842 (1)
  • InterPro:IPR005946 (1)
  • InterPro:IPR029057 (1)
  • InterPro:IPR029099 (1)
  • PROSITE:PS00114 (1)
  • Pfam:PF13793 (1)
  • Pfam:PF14572 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA prps1a-001 (1) 2311
    prps1a-002 (1) 1282
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM prps1a No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    prps1aContained in: [BAC] DKEY-114C15 (1) (order this)
    prps1aEncodes: [EST] cb96 (1) (order this), fa18f03, fb33h12, fd26g08
    [cDNA] MGC:55299 (order this), MGC:76932 (1) (order this), MGC:111881 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_213533 (1) 2292bp
    Genomic GenBank:BX640539 (1) 86752bp
    Select Tool
    Polypeptide UniProtKB:A0A0R4IW25 (1) 322aa
    Sequence Clusters UniGene:142104 (1)
    Sequence Information (all 36)
    OTHER prps1a GENE PAGES
  • Gene:140620 (1)
  • VEGA:OTTDARG00000018997 (1)
  • Ensembl(GRCz10):ENSDARG00000015524 (1)
  • ORTHOLOGY for prps1a (Chr: 5)
    Species Symbol Chromosome Accession # Evidence
    Human PRPS1 X
  • Gene:5631
  • OMIM:311850
  • HGNC:9462
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (22)