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General Information
ZIRC
ZFIN ID: ZDB-FISH-170223-12
Fish name: TU + MO8-chd7
Genotype: TU
Targeting Reagent: MO8-chd7
HUMAN DISEASE MODELED by TU + MO8-chd7
Human Disease Conditions Citations
CHARGE syndrome standard conditions Asad et al., 2016
GENE EXPRESSION
Gene expression in TU + MO8-chd7
RNA expression
Expressed Gene Structure Conditions Figures
crestin standard conditions Fig. 5Fig. S5 from Asad et al., 2016
dct standard conditions Fig. 4 from Asad et al., 2016
dlx2a standard conditions Fig. 7 from Asad et al., 2016
egr2b standard conditions Fig. S6 from Asad et al., 2016
foxd3 standard conditions Fig. 2Fig. 6 from Asad et al., 2016
isl2a standard conditions Fig. 5Fig. S5 from Asad et al., 2016
mbpa standard conditions Fig. 6 from Asad et al., 2016
mitfa standard conditions Fig. 4 from Asad et al., 2016
neurod1 standard conditions Fig. 5Fig. S5 from Asad et al., 2016
snai2 standard conditions Fig. 2 from Asad et al., 2016
sox2 standard conditions Fig. 2 from Asad et al., 2016
sox9a standard conditions Fig. 2Fig. 7 from Asad et al., 2016
sox9b standard conditions Fig. 7 from Asad et al., 2016
sox10 standard conditions Fig. 3 from Asad et al., 2016
tfap2a standard conditions Fig. 2 from Asad et al., 2016
tyr standard conditions Fig. 4 from Asad et al., 2016
Protein expression No data available
Reporter gene expression No data available
PHENOTYPE
Phenotype in TU + MO8-chd7
Phenotype Conditions Figures
brain glial cell (sensu Vertebrata) egr2b expression decreased amount, abnormal standard conditions Fig. S6 from Asad et al., 2016
cranial motor neuron isl2a expression decreased amount, abnormal standard conditions Fig. S5 from Asad et al., 2016
cranium glial cell foxd3 expression absent, abnormal standard conditions Fig. 6 from Asad et al., 2016
cranium glial cell (sensu Vertebrata) absent, abnormal standard conditions Fig. 6 from Asad et al., 2016
enteric neuron crestin expression decreased amount, abnormal standard conditions Fig. 5 from Asad et al., 2016
epibranchial cartilage neuroblast neurod1 expression decreased amount, abnormal standard conditions Fig. 5 from Asad et al., 2016
eye iridophore absent, abnormal standard conditions Fig. 4 from Asad et al., 2016
head decreased size, abnormal standard conditions Fig. 7 from Asad et al., 2016
head neuroblast neurod1 expression decreased amount, abnormal standard conditions Fig. S5 from Asad et al., 2016
lateral line glial cell egr2b expression decreased amount, abnormal standard conditions Fig. S6 from Asad et al., 2016
lateral line glial cell (sensu Vertebrata) foxd3 expression increased amount, abnormal standard conditions Fig. 6 from Asad et al., 2016
melanocyte tyr expression decreased amount, abnormal standard conditions Fig. 4 from Asad et al., 2016
melanocyte dct expression decreased amount, abnormal standard conditions Fig. 4 from Asad et al., 2016
migratory neural crest mislocalised, abnormal standard conditions Fig. 3 from Asad et al., 2016
motor neuron isl2a expression decreased amount, abnormal standard conditions Fig. 5 from Asad et al., 2016
myelinating Schwann cell mbpa expression decreased amount, abnormal standard conditions Fig. 6 from Asad et al., 2016
myelinating Schwann cell mbpa expression decreased distribution, abnormal standard conditions Fig. 6 from Asad et al., 2016
myelinating Schwann cell foxd3 expression increased amount, abnormal standard conditions Fig. 6 from Asad et al., 2016
myelinating Schwann cell myelination disrupted, abnormal standard conditions Fig. 6 from Asad et al., 2016
neural crest foxd3 expression increased amount, abnormal standard conditions Fig. 2 from Asad et al., 2016
neural crest sox10 expression spatial pattern, abnormal standard conditions Fig. 3 from Asad et al., 2016
neural crest melanoblast mitfa expression increased amount, abnormal standard conditions Fig. 4 from Asad et al., 2016
neural crest cell sox9a expression decreased amount, abnormal standard conditions Fig. 2 from Asad et al., 2016
neural crest cell snai2 expression decreased amount, abnormal standard conditions Fig. 2 from Asad et al., 2016
neural crest cell sox10 expression decreased amount, abnormal standard conditions Fig. 3 from Asad et al., 2016
neural crest cell migration delayed, abnormal standard conditions Fig. 3 from Asad et al., 2016
neural crest cell migration disrupted, abnormal standard conditions Fig. 2Fig. 3 from Asad et al., 2016
neural keel sox2 expression decreased amount, abnormal standard conditions Fig. 2 from Asad et al., 2016
neural plate border sox10 expression decreased amount, abnormal standard conditions Fig. 3 from Asad et al., 2016
neuromast absent, abnormal standard conditions Fig. 5 from Asad et al., 2016
neuromast decreased amount, abnormal standard conditions Fig. 5 from Asad et al., 2016
pericardium edematous, abnormal standard conditions Fig. 7 from Asad et al., 2016
perichondrium sox9b expression decreased amount, abnormal standard conditions Fig. 7 from Asad et al., 2016
perichondrium disorganized, abnormal standard conditions Fig. 7 from Asad et al., 2016
pharyngeal arch chondrocyte sox9a expression absent, abnormal standard conditions Fig. 7 from Asad et al., 2016
pharyngeal arch neural crest cell dlx2a expression decreased amount, abnormal standard conditions Fig. 7 from Asad et al., 2016
sensory neuron isl2a expression decreased amount, abnormal standard conditions Fig. 5 from Asad et al., 2016
somite foxd3 expression increased amount, abnormal standard conditions Fig. 2 from Asad et al., 2016
trunk iridophore absent, abnormal standard conditions Fig. 4 from Asad et al., 2016
vagal neural crest crestin expression decreased amount, abnormal standard conditions Fig. S5 from Asad et al., 2016
ventral mandibular arch absent, abnormal standard conditions Fig. 7 from Asad et al., 2016
whole organism decreased pigmentation, abnormal standard conditions Fig. 4 from Asad et al., 2016
whole organism foxd3 expression increased amount, abnormal standard conditions Fig. 2 from Asad et al., 2016
whole organism sox10 expression increased amount, abnormal standard conditions Fig. 3 from Asad et al., 2016
whole organism Melanin decreased amount, abnormal standard conditions Fig. 4 from Asad et al., 2016
whole organism melanocyte shape, abnormal standard conditions Fig. 4 from Asad et al., 2016

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