ZFIN Fish: s854Tg

ZFIN ID: ZDB-FISH-150901-26504

Fish name:	s854Tg
Genotype:	s854Tg
Targeting Reagent:	none

HUMAN DISEASE MODELED by s854Tg
No data available

GENE EXPRESSION
Gene expression in s854Tg

RNA expression

Expressed Gene	Structure	Conditions	Figures
alcama	hepatocyte plasma membrane liver pancreas	standard conditions	Fig. 3 from Sakaguchi et al., 2008 Fig. 1 from Shin et al., 2008
efnb1	gall bladder hepatoblast liver liver and biliary system digestive system duct pancreas	standard conditions	Fig. 6 from Thestrup et al., 2019 Fig. 1 from Cayuso et al., 2016
efnb2a	gall bladder intestine	standard conditions	Fig. 6 from Thestrup et al., 2019
ephb3b	liver and biliary system digestive system duct pancreas	standard conditions	Fig. 6 from Thestrup et al., 2019
ephb4a	gall bladder intestine	standard conditions	Fig. 6 from Thestrup et al., 2019
fgf10a	mesenchymal cell	standard conditions	Fig. 1 from Dong et al., 2007
ins	endocrine pancreas posterior pancreatic bud	standard conditions	Fig. 1 , Fig. 4 from Poulain et al., 2011 Fig. 6 from Shin et al., 2008
pdx1	pancreatic bud	standard conditions	Fig. 4 from Chung et al., 2008
prox1a	anterior pancreatic bud endocrine pancreas endoderm exocrine pancreas hepatoblast hepatocyte interrenal primordium liver liver primordium pancreas pancreas primordium	standard conditions	12 figures from 5 publications
	hepatoblast liver	chemical treatment: latrunculin B	Fig. 3 from Cayuso et al., 2016
raptor	digestive system	standard conditions	Fig. 4 from He et al., 2017
sox17	gall bladder liver	standard conditions	Fig. 3 from Shin et al., 2012
urb1	digestive system	standard conditions	Fig. 4, Fig. 5 from He et al., 2017
wnt2	lateral plate mesoderm paraxial mesoderm right side	standard conditions	Fig. 1 from Poulain et al., 2011

Protein expression

Antibody	Antigen Genes	Structure	Conditions	Figures
Ab2-ins		endocrine pancreas posterior pancreatic bud	standard conditions	Fig. 1, Fig. 2 from Dong et al., 2008
Ab-2F11		hepatic duct liver pancreas	standard conditions	Fig. 1 from Koltowska et al., 2013 Fig. 2 from Poulain et al., 2011
Ab3-prox1		anterior pancreatic bud endocrine pancreas endoderm exocrine pancreas hepatic duct hepatocyte liver liver primordium pancreas pancreatic bud	standard conditions	15 figures from 6 publications
Ab1-prkcz		hepatocyte apical plasma membrane	standard conditions	Fig. 3 from Sakaguchi et al., 2008
Ab2-prkcz		endodermal cell gut lateral plate mesoderm	standard conditions	Fig. S4 from Huang et al., 2008
Ab2-isl		endocrine cell endocrine pancreas mesenchymal cell pancreatic bud pancreatic system endocrine cell posterior pancreatic bud primary islet endocrine cell	standard conditions	Fig. 1 from Hochgreb-Hägele et al., 2013 Fig. 1 from Poulain et al., 2011 Fig. 1, Fig. 2 from Dong et al., 2008 Fig. 2 from Noël et al., 2008 Fig. 1 from Dong et al., 2007
Ab19-h3		liver	control	Fig. 4 from Liu et al., 2013
Ab1-pan-Cadherin		liver pancreas	standard conditions	Fig. 1 from Hochgreb-Hägele et al., 2013
Ab1-tjp1		digestive system duct cell-cell junction	standard conditions	Fig. 1 from Thestrup et al., 2019
Ab1-lama1		endoderm basement membrane integument basement membrane neural tube basement membrane notochord basement membrane posterior lateral plate mesoderm basement membrane somite basement membrane spinal cord basement membrane	standard conditions	Fig. 2 from Hochgreb-Hägele et al., 2013
zn-5	alcama	hepatocyte plasma membrane liver pancreas	standard conditions	Fig. 3 from Sakaguchi et al., 2008 Fig. 1 from Shin et al., 2008
Ab1-pdx1	pdx1	pancreatic bud	standard conditions	Fig. 4 from Chung et al., 2008

Reporter gene expression

Expressed Gene	Structure	Conditions	Figures
EGFP	gut intestine	standard conditions	Fig. 1 , Fig. 2 from Koltowska et al., 2013
GFP	anatomical system anterior pancreatic bud digestive system endocrine cell endocrine pancreas endoderm exocrine pancreas extrahepatic duct gall bladder gut hepatic duct hepatocyte intestine liver liver and biliary system endoderm pancreas pancreatic bud pancreatic duct presumptive swim bladder swim bladder swim bladder bud	standard conditions	39 figures from 22 publications
	endodermal cell liver	chemical treatment: 5-bromo-2'-deoxyuridine	Fig. 4 from Shin et al., 2008

PHENOTYPE
Phenotype in s854Tg

Phenotype	Conditions	Figures
hepatoblast mislocalised medially, abnormal	chemical treatment: latrunculin B	Fig. 3 from Cayuso et al., 2016
hepatoblast mislocalised posteriorly, abnormal	chemical treatment: latrunculin B	Fig. 3 from Cayuso et al., 2016
hepatocyte cell migration decreased occurrence, abnormal	chemical treatment: latrunculin B	Fig. 3 from Cayuso et al., 2016
intestine decreased size, abnormal	chemical treatment: sirolimus	Fig. 4 from He et al., 2017
liver prox1a expression increased distribution, abnormal	chemical treatment: latrunculin B	Fig. 3 from Cayuso et al., 2016
liver prox1a expression spatial pattern, abnormal	chemical treatment: latrunculin B	Fig. 3 from Cayuso et al., 2016
pancreas decreased size, abnormal	chemical treatment: sirolimus	Fig. 4 from He et al., 2017

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