ZFIN Fish: ml2Tg

ZFIN ID: ZDB-FISH-150901-25641

ZFIN ID: ZDB-FISH-150901-25641

Fish name:	ml2Tg
Genotype:	ml2Tg
Targeting Reagent:	none

HUMAN DISEASE MODELED by ml2Tg
No data available

GENE EXPRESSION
Gene expression in ml2Tg

RNA expression

Expressed Gene	Structure	Conditions	Figures
alcama	secondary motor neuron axon	control	Fig. 5 from Jao et al., 2012
calca	motor neuron	standard conditions	Fig. 4 from Zhong et al., 2012
chata	motor neuron spinal cord	physical alteration: anatomical structure	Fig. 4 from Reimer et al., 2008
chodl	motor neuron	standard conditions	Fig. 4 from Zhong et al., 2012
col15a1b	myotome extracellular matrix vertical myoseptum	standard conditions	Fig. 5 from Guillon et al., 2016
dcc	CaP motoneuron MiP motor neuron motor neuron RoP motor neuron spinal cord motor neuron	standard conditions	Fig. 8 from Rosenberg et al., 2014 Fig. 5 from Lim et al., 2011
	spinal cord motor neuron	transection: axon: neuron	Fig. 8 from Rosenberg et al., 2014
fignl1	secondary motor neuron microtubule	control	Fig. 2 from Fassier et al., 2018
gjd2b	interneuron spinal cord spinal cord neural tube	standard conditions	Fig. 3 from Carlisle et al., 2014
isl1a	(not) CaP motoneuron	standard conditions	Fig. 8 from Moreno et al., 2018
isl2a	CaP motoneuron	standard conditions	Fig. 8 from Moreno et al., 2018
isl2b	(not) CaP motoneuron	standard conditions	Fig. 8 from Moreno et al., 2018
ncaldb	whole organism	control	Fig. 3 from Riessland et al., 2017
nkx1.2lb	interneuron	standard conditions	Fig. 3 from Zhong et al., 2012
nxph1	spinal cord interneuron	control	Fig. 4 from Thomas-Jinu et al., 2013
plxna3	primary motor neuron	standard conditions	Fig. 2 from Feldner et al., 2007
si:ch73-1a9.3	skeletal muscle spinal cord	standard conditions	Fig. 7 from Gao et al., 2019
smn1	whole organism	control	Fig. 3 from Riessland et al., 2017
sst1.1	cerebrospinal fluid contacting neuron (not) spinal cord motor neuron	standard conditions	Fig. 5 from Djenoune et al., 2017
tac1	motor neuron	standard conditions	Fig. 4 from Zhong et al., 2012
vsx2	interneuron	standard conditions	Fig. 3 from Zhong et al., 2012

Protein expression

Antibody	Antigen Genes	Structure	Conditions	Figures
znp-1		CaP motoneuron axon terminus retinal inner plexiform layer (not) retinal outer plexiform layer skeletal muscle cell neuromuscular junction	standard conditions	Fig. 5 from Gribble et al., 2018 Fig. 3 from Riessland et al., 2017 Fig. 1, Fig. 9 from Fox et al., 2007
zn-12		Rohon-Beard neuron axon	standard conditions	Fig. 2 from Moreno et al., 2014
Ab1-mnx1		motor neuron	standard conditions	Fig. 2 from Zhong et al., 2012
Ab3-ins		pancreatic B cell	standard conditions	Fig. 1 from Arkhipova et al., 2012
Ab2-isl		CaP motoneuron endocrine cell motor neuron	standard conditions	Fig. 9 from Moreno et al., 2018 Fig. 1 from Arkhipova et al., 2012
Ab1-GABA		interneuron	standard conditions	Fig. 3 from Zhong et al., 2012
Ab1-chat		motor neuron	standard conditions	Fig. 2 from Zhong et al., 2012
Ab1-pax2		interneuron	standard conditions	Fig. 3 from Zhong et al., 2012
Ab3-sst		pancreatic D cell	standard conditions	Fig. 1 from Arkhipova et al., 2012
Ab2-gcg		pancreatic A cell	standard conditions	Fig. 1 from Arkhipova et al., 2012
Ab2-tuba		secondary motor neuron axon	control	Fig. 2 from Fassier et al., 2018
Ab-SV2		retina synaptic vesicle	standard conditions	Fig. 9 from Fox et al., 2007
Ab1-isl		motor neuron spinal cord	standard conditions	Fig. 2, Fig. 3 from Zhong et al., 2012 Fig. S2 from Reimer et al., 2008
Ab1-synapsin		CaP motoneuron axon terminus	standard conditions	Fig. 1 from Fox et al., 2007
zn-8	alcama	secondary motor neuron axon	control	Fig. 5 from Jao et al., 2012
Ab1-chat	chata	motor neuron spinal cord	physical alteration: anatomical structure	Fig. 4 from Reimer et al., 2008
Ab1-col15a1b	col15a1b	myotome extracellular matrix vertical myoseptum	standard conditions	Fig. 5 from Guillon et al., 2016
Ab1-fignl1	fignl1	secondary motor neuron microtubule	control	Fig. 2 from Fassier et al., 2018
Ab3-GFP	GFP	endocrine cell motor neuron pancreatic B cell	standard conditions	Fig. 1 from Arkhipova et al., 2012
Ab1-ncald	ncaldb	whole organism	control	Fig. 3 from Riessland et al., 2017
Ab3-smn1	smn1	whole organism	control	Fig. 3 from Riessland et al., 2017

Reporter gene expression

Expressed Gene	Structure	Conditions	Figures
EGFP	spinal cord motor neuron	control	Fig. S5 from Pilorge et al., 2016
GFP	CaP motoneuron endocrine cell endocrine pancreas interneuron MiP motor neuron motor neuron pancreas primordium pancreatic B cell pancreatic bud pectoral fin motor nerve axon pectoral fin motor nerve 1 axon pectoral fin motor nerve 2 axon pectoral fin motor nerve 3 axon pectoral fin motor nerve 4 axon posterior pancreatic bud primary motor neuron RoP motor neuron secondary motor neuron spinal cord motor neuron spinal cord neural tube motor neuron VaP motor neuron axon VeLD axon ventral horn spinal cord	standard conditions	56 figures from 34 publications
	motor neuron primary islet pancreatic B cell primary motor neuron spinal cord neuron	chemical treatment: drug	Fig. S5 from Ahmed Alfar et al., 2017 Fig. 7 from Casari et al., 2014 Fig. 9 from Johnson et al., 2014 Fig. 2 , Fig. 6 , Fig. 7 from Reimer et al., 2013
	motor neuron spinal cord	physical alteration: anatomical structure	Fig. 3, Fig. 5, Fig. 7, Fig. 8 from Rosenberg et al., 2014 Fig. 7 from Reimer et al., 2013 Fig. S5, Fig. S6 from Reimer et al., 2008

PHENOTYPE
Phenotype in ml2Tg

Phenotype	Conditions	Figures
motor neuron dead, abnormal	chemical treatment by environment: bisphenol A	Fig. S4 from Morrice et al., 2018
motor neuron decreased amount, abnormal	chemical treatment: LY 364947	Fig. 7 from Casari et al., 2014
motor neuron axon decreased length, abnormal	chemical treatment by environment: bisphenol A	Fig. S3 from Morrice et al., 2018
primary islet pancreatic B cell GFP expression increased distribution, abnormal	chemical treatment by environment: hydrogen peroxide	Fig. S5 from Ahmed Alfar et al., 2017
skeletal muscle apoptotic process increased occurrence, abnormal	chemical treatment by environment: bisphenol A	Fig. S7 from Morrice et al., 2018
spinal cord apoptotic process increased occurrence, abnormal	chemical treatment by environment: bisphenol A	Fig. S7 from Morrice et al., 2018

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