ZFIN ID: ZDB-FISH-150901-21534
Fish name: tbx1tm208/tm208
Genotype: tbx1tm208/tm208
Targeting Reagent: none
HUMAN DISEASE MODELED by tbx1tm208/tm208
Human Disease Conditions Citations
velocardiofacial syndrome standard conditions Piotrowski et al., 2003
DiGeorge syndrome standard conditions Piotrowski et al., 2003
GENE EXPRESSION
Gene expression in tbx1tm208/tm208
RNA expression
Expressed Gene Structure Conditions Figures
bmp4 standard conditions Fig. 3 with image from Choudhry et al., 2013
Fig. 3 with image from Piotrowski et al., 2000
col2a1a standard conditions Fig. 12 with image from Piotrowski et al., 2000
dkk1b standard conditions Fig. S10 with image from Alexander et al., 2014
dlx2a standard conditions Fig. 8 with image from Piotrowski et al., 2000
efnb2a standard conditions Fig. 7 with image from Piotrowski et al., 2000
egr2b standard conditions Fig. 7 with image from Piotrowski et al., 2000
elnb standard conditions Fig. 4 with image from Choudhry et al., 2013
en2a standard conditions Fig. 5 from Knight et al., 2008
foxa1 standard conditions Fig. 10 with image from Piotrowski et al., 2000
foxd3 standard conditions Fig. 5 with image from Piotrowski et al., 2000
fsta standard conditions Fig. 12 with image from Piotrowski et al., 2000
her9 standard conditions Fig. 5 with image from Radosevic et al., 2011
hoxb2a standard conditions Fig. 7 with image from Piotrowski et al., 2000
hoxb3a standard conditions Fig. 7 with image from Piotrowski et al., 2000
msx3 standard conditions Fig. 4 with image from Whitfield et al., 1996
myl7 standard conditions Fig. 1 with image from Choudhry et al., 2013
myod1 standard conditions Fig. 13 with image from Piotrowski et al., 2000
neurod1 standard conditions Fig. 7 with image from Maier et al., 2014
Fig. 5 with image from Radosevic et al., 2011
chemical treatment: 4-(diethylamino)benzaldehyde Fig. 7 with image from Maier et al., 2014
neurog1 standard conditions Fig. 5 with image from Radosevic et al., 2011
nkx2.3 standard conditions Fig. 10 with image from Piotrowski et al., 2000
nkx2.5 standard conditions Fig. 10 with image from Piotrowski et al., 2000
notch1b standard conditions Fig. 3 with image from Choudhry et al., 2013
nppa standard conditions Fig. 3 with image from Choudhry et al., 2013
otx1 standard conditions Fig. 7 with image from Maier et al., 2014
Fig. 5 with image from Whitfield et al., 1996
chemical treatment: 4-(diethylamino)benzaldehyde Fig. 7 with image from Maier et al., 2014
phox2bb standard conditions Fig. 3 with image from Holzschuh et al., 2005
rag1 standard conditions Fig. 9 with image from Piotrowski et al., 2000
shha standard conditions Fig. 11 with image from Piotrowski et al., 2000
snai1b standard conditions Fig. 5 with image from Piotrowski et al., 2000
tbx1 standard conditions Fig. 5 with image from Radosevic et al., 2011
tbx2a standard conditions Fig. S5 with image from Choudhry et al., 2013
tbx3b standard conditions Fig. S5 with image from Choudhry et al., 2013
tbx5a standard conditions Fig. S5 with image from Choudhry et al., 2013
tbx20 standard conditions Fig. S5 with image from Choudhry et al., 2013
vcana standard conditions Fig. 3 with image from Choudhry et al., 2013
wnt11 standard conditions Fig. 6 with image,  Fig. S5 with image from Choudhry et al., 2013
Reporter gene expression No data available
PHENOTYPE
Phenotype in tbx1tm208/tm208
Phenotype Conditions Figures
anatomical system quality, abnormal standard conditions Fig. for (tm208) from Phenotype Annotation (1994-2006)
anterior crista primordium aplastic, abnormal standard conditions Fig. 3 with image from Piotrowski et al., 2000
Fig. 4 with image from Whitfield et al., 1996
aortic arch decreased amount, abnormal standard conditions Fig. 3 with image from Piotrowski et al., 2000
atrium decreased angle to cardiac ventricle, abnormal standard conditions Fig. 1 with image from Choudhry et al., 2013
atrium increased width, abnormal standard conditions Fig. 1 with image,  Fig. S1 with image from Choudhry et al., 2013
auditory capsule decreased size, abnormal standard conditions Fig. 5 with image from Piotrowski et al., 1996
auditory capsule malformed, abnormal standard conditions Fig. 5 with image from Piotrowski et al., 1996
bulbus arteriosus decreased length, abnormal standard conditions Fig. 4 with image from Choudhry et al., 2013
bulbus arteriosus immature, abnormal standard conditions Fig. 4 with image from Choudhry et al., 2013
bulbus arteriosus smooth muscle morphology, abnormal standard conditions Fig. 4 with image from Choudhry et al., 2013
cardiac muscle cell circular, abnormal standard conditions Fig. 2 with image from Choudhry et al., 2013
cardiac muscle cell shape, abnormal standard conditions Fig. 2 with image from Choudhry et al., 2013
cardiac ventricle increased width, abnormal standard conditions Fig. 1 with image,  Fig. S1 with image from Choudhry et al., 2013
cardiac ventricle shortened, abnormal standard conditions Fig. S1 with image from Choudhry et al., 2013
cartilage morphogenesis disrupted, abnormal standard conditions Fig. 2 with image,  Fig. 8 with image from Piotrowski et al., 2000
ceratobranchial cartilage decreased size, abnormal standard conditions Fig. 5 with image from Piotrowski et al., 1996
ceratohyal cartilage morphology, abnormal standard conditions Fig. 5 with image from Piotrowski et al., 1996
constrictor dorsalis morphology, abnormal standard conditions Fig. 5 from Knight et al., 2008
cranial ganglion morphology, normal standard conditions Fig. 7 with image from Piotrowski et al., 2000
digestive system development disrupted, abnormal standard conditions Fig. 12 with image from Piotrowski et al., 2000
dilatator operculi aplastic, abnormal standard conditions Fig. 13 with image from Piotrowski et al., 2000
endoderm development disrupted, abnormal standard conditions Fig. 3 with image from Holzschuh et al., 2005
epibranchial ganglion fused with epibranchial ganglion, abnormal standard conditions Fig. 3 with image from Holzschuh et al., 2005
epibranchial ganglion increased size, abnormal standard conditions Fig. 3 with image from Holzschuh et al., 2005
glossopharyngeal ganglion absent, abnormal standard conditions Fig. 3 with image from Holzschuh et al., 2005
heart decreased functionality, abnormal standard conditions Fig. S4 with image from Choudhry et al., 2013
heart straight, abnormal standard conditions Fig. 1 with image from Choudhry et al., 2013
heart contraction decreased rate, abnormal standard conditions Fig. S4 with image from Choudhry et al., 2013
heart jogging disrupted, abnormal standard conditions Fig. 1 with image from Choudhry et al., 2013
heart looping disrupted, abnormal standard conditions Fig. 1 with image from Choudhry et al., 2013
inner ear decreased size, abnormal standard conditions Fig. 6 with image from Piotrowski et al., 2000
Fig. 2 with image from Whitfield et al., 1996
inner ear quality, abnormal standard conditions Fig. for (tm208) from Phenotype Annotation (1994-2006)
inner ear structure, abnormal standard conditions Fig. 2 with image from Whitfield et al., 1996
intestine morphology, normal standard conditions Fig. 12 with image from Piotrowski et al., 2000
lateral crista primordium aplastic, abnormal standard conditions Fig. 3 with image from Piotrowski et al., 2000
Fig. 4 with image from Whitfield et al., 1996
levator arcus palatini aplastic, abnormal standard conditions Fig. 13 with image from Piotrowski et al., 2000
macula decreased amount, abnormal standard conditions Fig. 3 with image from Whitfield et al., 1996
mandibular arch skeleton morphology, abnormal standard conditions Table 2 from Whitfield et al., 1996
Meckel's cartilage inverted, abnormal standard conditions Fig. 5 with image from Piotrowski et al., 1996
Meckel's cartilage mislocalised posteriorly, abnormal standard conditions Fig. 5 with image from Piotrowski et al., 1996
Meckel's cartilage mislocalised ventrally, abnormal standard conditions Fig. 5 with image from Piotrowski et al., 1996
mesenchyme decreased size, abnormal standard conditions Fig. 12 with image from Piotrowski et al., 2000
mouth closure incomplete, abnormal standard conditions Fig. 4 with image from Piotrowski et al., 2000
mouth mislocalised posteriorly, abnormal standard conditions Fig. 2 with image,  Fig. 4 with image from Piotrowski et al., 2000
mouth quality, abnormal standard conditions Fig. for (tm208) from Phenotype Annotation (1994-2006)
neural crest cell normal amount, normal standard conditions Fig. 5 with image from Piotrowski et al., 2000
notochord mislocalised anteriorly, abnormal standard conditions Fig. 12 with image from Piotrowski et al., 2000
otic vesicle decreased size, abnormal standard conditions Fig. 2 with image from Piotrowski et al., 2000
Fig. 2 with image from Whitfield et al., 1996
palatoquadrate cartilage decreased size, abnormal standard conditions Fig. 5 with image from Piotrowski et al., 1996
parachordal cartilage malformed, abnormal standard conditions Fig. 2 with image from Piotrowski et al., 2000
parachordal cartilage mislocalised posteriorly, abnormal standard conditions Fig. 5 with image from Piotrowski et al., 1996
paraxial mesoderm size, normal standard conditions Fig. 12 with image from Piotrowski et al., 2000
pericardium edematous, abnormal standard conditions text only from Piotrowski et al., 2000
peripheral nervous system development process quality, normal standard conditions Fig. 7 with image from Piotrowski et al., 2000
pharyngeal arch aplastic, abnormal standard conditions Fig. 4 with image from Piotrowski et al., 2000
pharyngeal arch 2 morphology, normal standard conditions Fig. 9 with image from Piotrowski et al., 2000
pharyngeal arch 3-7 morphology, abnormal standard conditions Fig. 9 with image from Piotrowski et al., 2000
pharyngeal arch 3-7 neural crest cell fused with pharyngeal arch 3-7 neural crest cell, abnormal standard conditions Fig. 8 with image from Piotrowski et al., 2000
pharyngeal arch 3-7 skeleton decreased size, abnormal standard conditions Fig. 2 with image from Piotrowski et al., 2000
pharyngeal arch 3-7 skeleton quality, abnormal standard conditions Fig. for (tm208) from Phenotype Annotation (1994-2006)
pharyngeal arch cartilage decreased size, abnormal standard conditions Fig. 2 with image from Piotrowski et al., 2000
pharyngeal arch cartilage disorganized, abnormal standard conditions Fig. 6 with image from Piotrowski et al., 2000
pharyngeal arch cartilage fused with pharyngeal arch cartilage, abnormal standard conditions Fig. 2 with image,  Fig. 7 with image from Piotrowski et al., 2000
pharyngeal muscle development disrupted, abnormal standard conditions Fig. 5 from Knight et al., 2008
pharyngeal pouch aplastic, abnormal standard conditions Fig. 3 with image from Holzschuh et al., 2005
Fig. 7 with image,  Fig. 8 with image,  Fig. 9 with image from Piotrowski et al., 2000
pharyngeal pouch decreased amount, abnormal standard conditions Fig. 9 with image from Piotrowski et al., 2000
pharyngeal pouch malformed, abnormal standard conditions Fig. 3 with image from Holzschuh et al., 2005
pharynx malformed, abnormal standard conditions Fig. 11 with image,  Fig. 12 with image from Piotrowski et al., 2000
pharynx development hypotrophic growth, abnormal standard conditions Fig. 12 with image from Piotrowski et al., 2000
posterior crista primordium aplastic, abnormal standard conditions Fig. 3 with image from Piotrowski et al., 2000
Fig. 4 with image from Whitfield et al., 1996
semicircular canal aplastic, abnormal standard conditions Fig. 2 with image from Piotrowski et al., 2000
Fig. 2 with image from Whitfield et al., 1996
semicircular canal morphogenesis arrested, abnormal standard conditions Fig. 4 with image from Whitfield et al., 1996
sensory system quality, abnormal standard conditions Fig. for (tm208) from Phenotype Annotation (1994-2006)
swim bladder non-functional, abnormal standard conditions text only from Piotrowski et al., 2000
thymus aplastic, abnormal standard conditions Fig. 9 with image from Piotrowski et al., 2000
ventral transverse aplastic, abnormal standard conditions Fig. 13 with image from Piotrowski et al., 2000
whole organism circling, abnormal standard conditions Table 2 from Whitfield et al., 1996
whole organism lethal (sensu genetics), abnormal standard conditions Fig. for (tm208) from Phenotype Annotation (1994-2006)
whole organism movement behavioral quality, abnormal standard conditions Table 2 from Whitfield et al., 1996
whole organism viability, abnormal standard conditions text only from Piotrowski et al., 2000
Table 2 from Whitfield et al., 1996

CITATIONS  (15)

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