ZFIN Fish: WT + MO1-foxc1b + MO2-foxc1a

ZFIN ID: ZDB-FISH-150901-14620

ZFIN ID: ZDB-FISH-150901-14620

Fish name:	WT + MO1-foxc1b + MO2-foxc1a
Genotype:	WT
Targeting Reagent:	MO2-foxc1a , MO1-foxc1b

HUMAN DISEASE MODELED by WT + MO1-foxc1b + MO2-foxc1a

Human Disease	Conditions	Citations
cerebrovascular disease	standard conditions	French et al., 2014
glaucoma	standard conditions	Skarie et al., 2009

GENE EXPRESSION
Gene expression in WT + MO1-foxc1b + MO2-foxc1a

RNA expression

Expressed Gene	Structure	Conditions	Figures
cldn5b	blood vessel endothelium bicellular tight junction	standard conditions	Fig. S5 from French et al., 2014
col4a1	vasculature basement membrane	standard conditions	Fig. S5 from French et al., 2014
fgf19	eye head mesenchyme retina retinal pigmented epithelium	standard conditions	Fig. 4 from Tamimi et al., 2006
flt4	cardinal system dorsal aorta hyaloid vessel	standard conditions	Fig. 4 from Skarie et al., 2009
foxd3	neural crest cell	control	Fig. S4 from French et al., 2014
foxo1a	head mesenchyme	standard conditions	Fig. 5 from Berry et al., 2008
foxo1b	eye pharyngeal arch	standard conditions	Fig. 5 from Berry et al., 2008
pdgfra	cranial blood vessel head mesenchyme neural crest cell	standard conditions	Fig. 2 from French et al., 2014
pdgfrb	cranial blood vessel head mesenchyme neural crest cell	standard conditions	Fig. 2 from French et al., 2014

Protein expression

Antibody	Antigen Genes	Structure	Conditions	Figures
Ab1-lama1		eye basement membrane	standard conditions	Fig. 7 from Skarie et al., 2009

Reporter gene expression No data available

PHENOTYPE
Phenotype in WT + MO1-foxc1b + MO2-foxc1a

Phenotype	Conditions	Figures
blood circulation disrupted, abnormal	standard conditions	Fig. 2 from Skarie et al., 2009
brain hemorrhagic, abnormal	standard conditions	Fig. 1, Fig. 2 from French et al., 2014
brain hydrocephalic, abnormal	standard conditions	Fig. 2, Fig. 8 from Skarie et al., 2009
brain hydrocephalic, abnormal	chemical treatment: N-phenylthiourea	Fig. 7 from Acharya et al., 2011
brain vasculature morphology, abnormal	standard conditions	Fig. S2 from French et al., 2014
central nervous system hemorrhagic, abnormal	standard conditions	Fig. 2, Fig. 8 from Skarie et al., 2009
corneal endothelium aplastic, abnormal	standard conditions	Fig. 3 from Skarie et al., 2009
corneal stroma structure, abnormal	standard conditions	Fig. 3 from Skarie et al., 2009
eye apoptotic, abnormal	standard conditions	Fig. 7 from Berry et al., 2008
eye decreased size, abnormal	standard conditions	Fig. 2, Fig. 3 from Skarie et al., 2009
eye hemorrhagic, abnormal	standard conditions	Fig. 2, Fig. 8 from Skarie et al., 2009
eye hemorrhagic, abnormal	chemical treatment: N-phenylthiourea	Fig. 7 from Acharya et al., 2011
eye basement membrane disorganized, abnormal	standard conditions	Fig. 6 from Skarie et al., 2009
eye basement membrane morphology, abnormal	standard conditions	Fig. 7 from Skarie et al., 2009
hyaloid vessel decreased amount, abnormal	standard conditions	Fig. 3 from Skarie et al., 2009
hyaloid vessel dilated, abnormal	standard conditions	Fig. 3 from Skarie et al., 2009
hyaloid vessel morphology, abnormal	standard conditions	Fig. 6 from Skarie et al., 2009
lens development in camera-type eye delayed, abnormal	standard conditions	Fig. 3 from Skarie et al., 2009
neural crest cell migration delayed, abnormal	standard conditions	Fig. S4 from French et al., 2014
pericardium edematous, abnormal	standard conditions	Fig. 2 from Skarie et al., 2009
periocular mesenchyme disorganized, abnormal	standard conditions	Fig. 3 from Skarie et al., 2009
retina layer formation delayed, abnormal	standard conditions	Fig. 3 from Skarie et al., 2009
ventricular system distended, abnormal	standard conditions	Fig. 3 from Skarie et al., 2009
whole organism decreased length, abnormal	chemical treatment: N-phenylthiourea	Fig. 7 from Acharya et al., 2011

CITATIONS (6)