ZFIN ID: ZDB-FISH-150901-11558
Fish name: gli2aty119/ty119
Genotype: gli2aty119/ty119
Targeting Reagent: none

HUMAN DISEASE MODELED by gli2aty119/ty119
No data available
GENE EXPRESSION
Gene expression in gli2aty119/ty119
Expressed Gene Structure Conditions Figures
alcama hindbrain, rhombomere standard conditions Fig. 1 with imageFig. 5 with image from Vanderlaan et al., 2005
dlx2a forebrain standard conditions Fig. 1 with image from Bergeron et al., 2011
efemp2a adaxial cell standard conditions Fig. 7 with image from Wang et al., 2013
egr2b rhombomere 3, rhombomere 5 standard conditions Fig. 2 with imageFig. 3 with imageFig. 5 with imageFig. 6 with imageFig. 10 with image from Vanderlaan et al., 2005
rhombomere 3, rhombomere 5 chemical treatment: Cyclopamine Fig. 2 with image from Vanderlaan et al., 2005
en1a (not) muscle pioneer, unspecified standard conditions Fig. 4 with image from Ochi et al., 2006
Fig. 4 from Kawakami et al., 2005
flt4 (not) unspecified standard conditions text only from Lawson et al., 2002
foxe3 ectoderm, solid lens vesicle standard conditions Fig. 3 from Swindell et al., 2008
fras1 adaxial cell, neural tube ventral region standard conditions Fig. 7 with image from Wang et al., 2013
gfap forebrain standard conditions Fig. 4 with imageFig. 5 with imageFig. 6 with image from Barresi et al., 2005
gh1 (not) adenohypophyseal placode standard conditions Fig. S2 with image from Bergeron et al., 2011
gli2a forebrain, rhombomere 4, rhombomere 5 standard conditions Fig. 8 with image from Vanderlaan et al., 2005
hhip (not) paraxial mesoderm standard conditions Fig. S1 with image from Ochi et al., 2006
hnmt adaxial cell standard conditions Fig. 7 with image from Wang et al., 2013
isl1 epiphysis, rhombomere 4 standard conditions Fig. 8 with image from Vanderlaan et al., 2005
lamc1 adaxial cell, neural tube standard conditions Fig. 7 with image from Wang et al., 2013
lrp4 adaxial cell standard conditions Fig. 7 with image from Wang et al., 2013
myl10 adaxial cell standard conditions Fig. 7 with image from Wang et al., 2013
myod1 adaxial cell, somite, tail bud standard conditions Fig. 4 with image from Wang et al., 2013
Fig. 6 with image from Groves et al., 2005
Fig. 8 with image from Karlstrom et al., 2003
Fig. 1 with imageFig. 3 with image from Lewis et al., 1999
Fig. 1 from van Eeden et al., 1998
Fig. 9 with image from van Eeden et al., 1996
somite chemical treatment: SU5402 Fig. 6 with image from Groves et al., 2005
nkx2.1 diencephalon, hypothalamus, telencephalon standard conditions Fig. 9 with image from Karlstrom et al., 2003
nkx2.2a (not) adenohypophyseal placode, central nervous system ventral region, forebrain (all 10) expand standard conditions Fig. 2 with image from Wang et al., 2013
Fig. 2 with imageFig. 3 with imageFig. 5 with imageFig. 8 with image from Vanderlaan et al., 2005
text only from Sekimizu et al., 2004
Fig. 1 with imageFig. 8 with image from Karlstrom et al., 2003
Fig. 5 from Karlstrom et al., 1999
(not) neural tube chemical treatment: Cyclopamine Fig. 2 with image from Vanderlaan et al., 2005
nr5a2 endoderm, neural tube, (not) slow muscle cell standard conditions Fig. 3 with image from Sheela et al., 2005
nrp1a primary motor neuron standard conditions Fig. 6 with image from Sato-Maeda et al., 2006
ntn1a neural tube, rhombomere standard conditions Fig. 2 with imageFig. 3 with imageFig. 6 with image from Vanderlaan et al., 2005
olig2 forebrain, midbrain, motor neuron standard conditions Fig. 2 with imageFig. 6 with image from Wang et al., 2013
pax6a brain, forebrain, forebrain midbrain boundary (all 6) expand standard conditions text only from Sekimizu et al., 2004
Fig. 1 with image from Karlstrom et al., 2003
Fig. 5 from Karlstrom et al., 1999
pomca adenohypophyseal placode, hypothalamus standard conditions Fig. S2 with image from Bergeron et al., 2011
prdm1a adaxial cell standard conditions Fig. 2 with image from Wang et al., 2013
prdm8b adaxial cell standard conditions Fig. 7 with image from Wang et al., 2013
prl adenohypophyseal placode standard conditions Fig. S2 with image from Bergeron et al., 2011
ptch2 (not) adaxial cell, brain, central nervous system ventral region (all 6) expand standard conditions Fig. 2 with image from Wang et al., 2013
Fig. 2 with imageFig. 10 with image from Vanderlaan et al., 2005
Fig. 1 with imageFig. 8 with image from Karlstrom et al., 2003
Fig. 5 from Karlstrom et al., 1999
Fig. 1 with imageFig. 3 with imageFig. 4 with image from Lewis et al., 1999
quo adaxial cell standard conditions Fig. 7 with image from Wang et al., 2013
sema3d forebrain standard conditions Fig. 5 with image from Barresi et al., 2005
sema3h (not) somite standard conditions Fig. 2 with image from Stevens et al., 2005
shha medial floor plate standard conditions Fig. 5 from Karlstrom et al., 1999
slit1a forebrain standard conditions Fig. 1 with image from Bergeron et al., 2011
Fig. 5 with image from Barresi et al., 2005
slit2 forebrain standard conditions Fig. 1 with image from Bergeron et al., 2011
Fig. 5 with image from Barresi et al., 2005
slit3 forebrain standard conditions Fig. 5 with image from Barresi et al., 2005
smyd1b somite standard conditions Fig. 6 with image from Du et al., 2006
tp73 (not) slow muscle cell standard conditions Fig. 4 with image from Rentzsch et al., 2003
vegfaa unspecified standard conditions text only from Lawson et al., 2002
wnt4b (not) lateral floor plate, medial floor plate standard conditions Fig. 3 from Liu et al., 2000
PHENOTYPE 
Phenotype in gli2aty119/ty119
Phenotype Conditions Figures
adaxial cell absent, abnormal standard conditions Fig. 1 from van Eeden et al., 1998
Fig. 9 with image from van Eeden et al., 1996
adenohypophysis aplastic, abnormal standard conditions Fig. 3 from Swindell et al., 2008
anterior commissure decreased size, abnormal standard conditions Fig. 4 from Karlstrom et al., 1999
blood circulation disrupted, abnormal standard conditions Table 1 from Chen et al., 1996
Fig. 8 with image from van Eeden et al., 1996
brain quality, abnormal standard conditions Fig. for (ty119) with image from Phenotype Annotation (1994-2006)
CaP motoneuron axon decreased amount, abnormal standard conditions Fig. 5 with image from van Eeden et al., 1996
cell migration involved in kidney development disrupted, abnormal standard conditions Fig. 2 with image from Majumdar et al., 2000
central nervous system projection neuron axonogenesis disrupted, abnormal standard conditions Fig. 5 with image from van Eeden et al., 1996
ceratobranchial 5 bone decreased length, abnormal standard conditions Fig. 4 with image from Wiweger et al., 2012
ceratobranchial 5 bone has fewer parts of type ceratobranchial 5 tooth, abnormal standard conditions Fig. 4 with image from Wiweger et al., 2012
ceratobranchial 5 tooth decreased length, abnormal standard conditions Fig. 4 with image from Wiweger et al., 2012
ceratobranchial 5 tooth increased width, abnormal standard conditions Fig. 4 with image from Wiweger et al., 2012
chondrocranium morphology, abnormal standard conditions Table 2 from Piotrowski et al., 1996
cranial neural crest cell mislocalised ventrally, abnormal standard conditions Table 2 from Piotrowski et al., 1996
esophageal epithelium disorganized, abnormal standard conditions Fig. 9 with image from Wallace et al., 2003
esophageal epithelium epithelial cell differentiation disrupted, abnormal standard conditions Fig. 9 with image from Wallace et al., 2003
esophagus malformed, abnormal standard conditions Fig. 9 with image from Wallace et al., 2003
ethmoid cartilage aplastic, abnormal standard conditions Fig. 8 from Brand et al., 1996
eye decreased distance eye, abnormal standard conditions Fig. 2 from Brand et al., 1996
Fig. 8 with image from van Eeden et al., 1996
eye mislocalised medially, abnormal standard conditions Fig. 2 from Brand et al., 1996
fast muscle cell absent, abnormal standard conditions Fig. 7 from Wolff et al., 2003
floor plate hypoplastic, abnormal standard conditions Table 1 from Brand et al., 1996
forebrain physical object quality, abnormal standard conditions Fig. 1 with image from Bergeron et al., 2011
forebrain regionalization process quality, abnormal standard conditions Fig. 1 with image from Bergeron et al., 2011
horizontal myoseptum absent, abnormal standard conditions Fig. 2 from van Eeden et al., 1998
horizontal myoseptum aplastic, abnormal standard conditions Fig. 8 with image from van Eeden et al., 1996
larval locomotory behavior process quality, abnormal standard conditions Table 4 from Granato et al., 1996
lens increased amount, abnormal standard conditions Fig. 3 from Swindell et al., 2008
lens mislocalised, abnormal standard conditions Fig. 3 from Swindell et al., 2008
MiP motor neuron axon decreased amount, abnormal standard conditions Fig. 5 with image from van Eeden et al., 1996
muscle cell differentiation decreased occurrence, abnormal standard conditions Fig. 6 with image from Lobbardi et al., 2011
muscle pioneer absent, abnormal standard conditions Fig. 6 with image from Lobbardi et al., 2011
Fig. 7 from Wolff et al., 2003
musculoskeletal movement quality, abnormal standard conditions Fig. for (ty119) with image from Phenotype Annotation (1994-2006)
myoseptum aplastic, abnormal standard conditions Table 1 from Brand et al., 1996
nervous system quality, abnormal standard conditions Fig. for (ty119) with image from Phenotype Annotation (1994-2006)
neural tube quality, abnormal standard conditions Fig. for (ty119) with image from Phenotype Annotation (1994-2006)
optic chiasm absent, abnormal standard conditions Fig. 4 from Karlstrom et al., 1999
optic chiasm malformed, abnormal standard conditions Fig. 7 from Brand et al., 1996
optic nerve formation disrupted, abnormal standard conditions Fig. 4 from Karlstrom et al., 1999
pericardium edematous, abnormal standard conditions Fig. 8 with image from van Eeden et al., 1996
pharyngeal arch 3-7 mislocalised ventrally, abnormal standard conditions Fig. 8 with image from van Eeden et al., 1996
post-vent region curved, abnormal standard conditions Fig. 8 with image from van Eeden et al., 1996
post-vent region curved ventral, abnormal standard conditions Fig. 1 with image from Schwend et al., 2010
Table 1 from Brand et al., 1996
postoptic commissure absent, abnormal standard conditions Fig. 4 from Karlstrom et al., 1999
proctodeum atretic, abnormal standard conditions Fig. 3 with image from Parkin et al., 2009
proctodeum malformed, abnormal standard conditions Fig. 3 with image from Parkin et al., 2009
pronephric glomerulus increased amount, abnormal standard conditions Fig. 2 with image from Majumdar et al., 2000
pronephric glomerulus mislocalised laterally, abnormal standard conditions Fig. 2 with image from Majumdar et al., 2000
response to external stimulus quality, abnormal standard conditions Fig. for (ty119) with image from Phenotype Annotation (1994-2006)
retinal ganglion cell axon displaced to diencephalon, abnormal standard conditions Table 1 from Karlstrom et al., 1996
retinal ganglion cell axon ipsilateral to eye, abnormal standard conditions Table 1 from Karlstrom et al., 1996
retinal ganglion cell axon misrouted, abnormal standard conditions Table 1 from Karlstrom et al., 1996
retinal ganglion cell axon guidance disrupted, abnormal standard conditions Fig. 4 from Karlstrom et al., 1999
Fig. 7 from Brand et al., 1996
Table 3 from van Eeden et al., 1996
retinal ganglion cell axon guidance process quality, abnormal standard conditions Table 1 from Karlstrom et al., 1996
slow muscle cell absent, abnormal standard conditions Fig. 6 with image from Lobbardi et al., 2011
Fig. 2 from Du et al., 2001
smoothened signaling pathway decreased occurrence, abnormal standard conditions Fig. 6 with image from Lobbardi et al., 2011
somite lacks all parts of type muscle pioneer, abnormal standard conditions Fig. 9 with image from van Eeden et al., 1996
somite quality, abnormal standard conditions Fig. for (ty119) with image from Phenotype Annotation (1994-2006)
somite U-shaped, abnormal standard conditions Fig. 1 with image from Schwend et al., 2010
Fig. 1 with image from Karlstrom et al., 2003
striated muscle cell development arrested, abnormal standard conditions Fig. 2 from Du et al., 2001
third ventricle increased size, abnormal standard conditions Table 1 from Karlstrom et al., 1996
trabecula cranii fused with trabecula cranii, abnormal standard conditions Fig. 8 from Brand et al., 1996
whole organism curved ventral, abnormal standard conditions Fig. 1 with image from Karlstrom et al., 2003
whole organism decreased behavioural activity, abnormal standard conditions Table 4 from Granato et al., 1996
whole organism lethal (sensu genetics), abnormal standard conditions Fig. for (ty119) with image from Phenotype Annotation (1994-2006)
whole organism movement behavioral quality, abnormal standard conditions Table 1 from Brand et al., 1996
Table 3 from van Eeden et al., 1996

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