FIGURE

Fig. 7

ID
ZDB-FIG-190819-5
Publication
Su et al., 2019 - A Novel AURKA Mutant-Induced Early-Onset Severe Hepatocarcinogenesis Greater than Wild-Type via Activating Different Pathways in Zebrafish
Other Figures
All Figure Page
Back to All Figure Page
Fig. 7

The immunoreactive score (IRS) of immunohistochemistry for the proliferating cell nuclear antigen (PCNA) was greater in AURKA(V352I) and AURKA(WT) than in control fish at 5 and 7 months. (A) Representative images of immunohistochemistry (IHC) staining for PCNA in control, AURKA(WT), and AURKA(V352I) at 3, 5, 7, 9, and 11 months; (B) Selected enlarged images show the nuclear signals of PCNA from AURKA(WT)—7 M and AURKA(V352I)—5 M; (C) Statistical analysis of PCNA immunostaining IRS score at 3, 5, 7, 9, and 11 months. IRS score of control fish (Tg(fabp10a:EGFP-mCherry) abbreviated as mC, AURKA(WT) and AURKA(V352I) is shown in red (3 M), orange (5 M), green (7 M), purple (9 M), and blue (11 M). Statistical analysis of results was performed using a two-tailed Student’s t-test. The error bar means standard deviation. Asterisks (*) represent the level of significance. * p-value ≤ 0.05; ** p-value ≤ 0.01; *** p-value ≤ 0.001.

Expression Data

Expression Detail
Antibody Labeling
Phenotype Data
Fish:
Observed In:
Stage: Adult

Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Cancers