ZFIN ID: ZDB-FIG-190626-37
Camargo-Sosa et al., 2019 - Endothelin receptor Aa regulates proliferation and differentiation of Erb-dependent pigment progenitors in zebrafish. PLoS Genetics   15:e1007941 Full text @ PLoS Genet.
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Conditions:
Observed In:
Stage: Day 4

Fig. S4

Inhibition of MEK rescues the pde phenotype.

Treatment with increasing concentrations of the MEK inhibitors U0126 (2.5–7.6 μM) and PD 325901 (0.25–0.75μM), from 6–96 hpf, shows increasing rescue of the ectopic pigment cells. Scale bar = 100 μm (A-G).

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
ednraatj262/tj262 control Day 4 pigment cell mislocalised, abnormal
Day 4 trunk ventral region has extra parts of type pigment cell, abnormal
ednraatj262/tj262 chemical treatment by environment: PD 0325901 Day 4 pigment cell mislocalised, ameliorated
Day 4 trunk ventral region has extra parts of type pigment cell, ameliorated
ednraatj262/tj262 chemical treatment by environment: U0126 Day 4 pigment cell mislocalised, ameliorated
Day 4 trunk ventral region has extra parts of type pigment cell, ameliorated
Acknowledgments:
ZFIN wishes to thank the journal PLoS Genetics for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ PLoS Genet.