ZFIN ID: ZDB-FIG-180927-28
Xiao et al., 2018 - The roles of SMYD4 in epigenetic regulation of cardiac development in zebrafish. PLoS Genetics   14:e1007578 Full text @ PLoS Genet.
Observed In:
Stage: Long-pec

Fig. 4

Phenotypical analyses of MZsmyd4L544Efs*1 embryos.

(A) The p-H3(S10) immunofluorescence staining showed decreased cell proliferative activity in MZsmyd4L544Efs*1 cardiomyocytes at 48 hpf. The number of p-H3 (S10) positive cells in the MZsmyd4L544Efs*1 ventricles was significantly decreased when compared to the control group (p<0.01, **); (B) The abnormal ventricular morphology of the adult MZsmyd4L544Efs*1 hearts compared to the morphology of control adult hearts; (C) Histological sections and H&E staining images of the adult MZsmyd4L544Efs*1 and control hearts, demonstrating significant thickening of the compact ventricular wall. (The red arrows showed that in the similar compact zone of the ventricle). The quantitative analysis displayed that the thickness of the ventricle compact zone was significantly increased in adult MZsmyd4 L544Efs*1 hearts compared to Tg(cmcl2:GFP) (p<0.05, *).

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
smyd4zf3020/zf3020; zf2036Tg standard conditions Long-pec cardiac muscle cell cell population proliferation decreased occurrence, abnormal
Long-pec compact layer of ventricle increased thickness, abnormal
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