ZFIN ID: ZDB-FIG-180918-7
Yang et al., 2018 - Central role of autophagic UVRAG in melanogenesis and the suntan response. Proc. Natl. Acad. Sci. USA   115(33):E7728-E7737 Full text @ Proc. Natl. Acad. Sci. USA
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Knockdown Reagents:
Observed In:
Stage: Long-pec

Fig. 3

UVRAG is required for melanocyte development in zebrafish in vivo. (A) Representative images of 48 h postfertilization (hpf) zebrafish embryos injected with control morpholino (MO) or MO targeting uvrag, pmel, or tyr. Rescue of uvrag MO-mediated depigmentation is shown by coinjection of human uvrag mRNA. Box highlights area of enlargement visualized in Insets. Numbers on each panel indicate the number of embryos showing the representative phenotype per total number of embryos examined. (B) Quantitative measurement shows significantly decreased pigmentation in uvrag MO and pmel MO group compared with the control group. Means were calculated from the data collected from three independent experiments (n = 50). ***P < 0.001; ****P < 0.0001.

Gene Expression DetailsNo data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
TU + MO1-uvrag standard conditions Long-pec melanocyte decreased amount, abnormal
Long-pec whole organism decreased pigmentation, abnormal
TU + MO3-pmela standard conditions Long-pec melanocyte decreased amount, abnormal
Long-pec whole organism decreased pigmentation, abnormal
TU + MO3-tyr standard conditions Long-pec melanocyte decreased amount, abnormal
Long-pec whole organism decreased pigmentation, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Proc. Natl. Acad. Sci. USA for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Proc. Natl. Acad. Sci. USA