ZFIN ID: ZDB-FIG-180824-48
Sturtzel et al., 2018 - FOXF1 Mediates Endothelial Progenitor Functions and Regulates Vascular Sprouting. Frontiers in bioengineering and biotechnology   6:76 Full text @ Front Bioeng Biotechnol
PHENOTYPE:
Fish:
Knockdown Reagents:
Observed In:
Stage Range: Long-pec to Day 5

Fig. 5

Downregulation of FOXF1 in zebrafish impairs vascular development. (A–C) Light and confocal microscopic images and quantification (at least 100 embryos per group) of tg(fli1:EGFP) embryos at 48 h post-fertilization injected with control (CoMO) or FoxF1 morpholino (SB-FoxF1-MO). Injection of the FoxF1 morpholino resulted in an impaired formation of the ISVs (white marks), DLAVs (yellow marks), and PLs (blue marks). (D–F) Light and confocal microscopic images and quantification (at least 100 embryos per group) of tg(fli1:EGFP) embryos at 120 h post-fertilization injected with control (CoMO) or FoxF1 morpholino (SB-FoxF1-MO). Injection of the FoxF1 morpholino resulted in an impaired formation of the TD (red marks).

Gene Expression DetailsNo data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
y1Tg + MO1-foxf1 + MO4-tp53 standard conditions Long-pec dorsal longitudinal anastomotic vessel morphology, abnormal
Long-pec intersegmental vessel morphology, abnormal
Long-pec sprouting angiogenesis disrupted, abnormal
Long-pec vascular lymphangioblast absent, abnormal
Day 5 thoracic duct absent, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Frontiers in bioengineering and biotechnology for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Front Bioeng Biotechnol