FIGURE

Fig. 2

ID
ZDB-FIG-171117-2
Publication
Lee et al., 2016 - Myc and Fgf Are Required for Zebrafish Neuromast Hair Cell Regeneration
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Fig. 2

Myc inhibition suppresses HC regeneration in zebrafish neuromasts.

(A) HCS1-labeled HC number was significantly reduced after treatment by c-MYC inhibitor 10058F4 that was dose-dependent. ***p<0.001. n = 20 larvae for each group. (B) A significant reduction in HC number was observed after the treatment by Int-H1-S6A, F8A, a peptide inhibitor of c-MYC, which was dose-dependent. ***p<0.001. n = 15 larvae for each group. Three independent experiments were performed for each comparison study with similar results. (C-H) Inhibitor Int-H1-S6A, F8A blocked the expression of c-myc target gene odc1. In situ hybridization showed up-regulation of odc1 expression in the neuromast 3 or 6 hrs after neomycin treatment (D, G); whereas Int-H1-S6A, F8A markedly suppressed odc1 expression (E, H). Scale bars: 10 μm.

Expression Data
Gene:
Fish:
Condition:
Anatomical Terms:
Stage: Day 5

Expression Detail
Antibody Labeling
Phenotype Data
Fish:
Conditions:
Observed In:
Stage Range: Day 5 to Days 7-13

Phenotype Detail
Acknowledgments
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