ZFIN ID: ZDB-FIG-170615-40
Liu et al., 2017 - Pathogenic Mutations in Retinitis Pigmentosa 2 Predominantly Result in Loss of RP2 Protein Stability in Human and Zebrafish. The Journal of biological chemistry   292(15):6225-6239 Full text @ J. Biol. Chem.
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Genes:
Antibodies:
Fish:
Anatomical Terms:
Stage Range: Days 30-44 to Adult
PHENOTYPE:
Fish:
Observed In:
Stage Range: Days 30-44 to Adult

Fig. 2 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
pde6b Ab1-pde6b WT standard conditions Days 30-44 eye WB
Ab1-pde6b Days 45-89 eye WB
Ab1-pde6b rp2hzu1/hzu1 standard conditions Days 30-44 eye WB
Ab1-pde6b Days 45-89 eye WB
Ab1-pde6b rp2hzu2/hzu2 standard conditions Days 30-44 eye WB
Ab1-pde6b Days 45-89 eye WB
rp2 Ab4-rp2 WT standard conditions Days 30-44 eye WB
Ab4-rp2 Days 45-89 eye WB
Ab4-rp2 rp2hzu1/hzu1 standard conditions Days 30-44 eye WB
Ab4-rp2 Days 45-89 eye WB
Ab4-rp2 rp2hzu2/hzu2 standard conditions Days 30-44 eye WB
Ab4-rp2 Days 45-89 eye WB
Antibody Labeling Details
Antibody Assay Fish Conditions Stage Anatomy
Ab1-arl3 WB WT standard conditions Days 30-44 eye
WB Days 45-89 eye
WB rp2hzu1/hzu1 standard conditions Days 30-44 eye
WB Days 45-89 eye
WB rp2hzu2/hzu2 standard conditions Days 30-44 eye
WB Days 45-89 eye
Ab1-gnb1 WB WT standard conditions Days 30-44 eye
WB Days 45-89 eye
WB rp2hzu1/hzu1 standard conditions Days 30-44 eye
WB Days 45-89 eye
WB rp2hzu2/hzu2 standard conditions Days 30-44 eye
WB Days 45-89 eye
Ab1-grk1 WB WT standard conditions Days 30-44 eye
WB Days 45-89 eye
WB rp2hzu1/hzu1 standard conditions Days 30-44 eye
WB Days 45-89 eye
WB rp2hzu2/hzu2 standard conditions Days 30-44 eye
WB Days 45-89 eye
Ab2-nsf WB WT standard conditions Days 30-44 eye
WB Days 45-89 eye
WB rp2hzu1/hzu1 standard conditions Days 30-44 eye
WB Days 45-89 eye
WB rp2hzu2/hzu2 standard conditions Days 30-44 eye
WB Days 45-89 eye
Ab3-gnat1 WB WT standard conditions Days 30-44 eye
WB Days 45-89 eye
WB rp2hzu1/hzu1 standard conditions Days 30-44 eye
WB Days 45-89 eye
WB rp2hzu2/hzu2 standard conditions Days 30-44 eye
WB Days 45-89 eye
Ab5-rho IHC WT standard conditions Adult photoreceptor outer segment layer
IHC rp2hzu2/hzu2 standard conditions Adult photoreceptor outer segment layer
Phenotype Details
Fish Conditions Stage Phenotype
rp2hzu1/hzu1 standard conditions Days 30-44 eye ab1-grk1 labeling decreased amount, abnormal
Days 30-44 eye pde6b expression decreased amount, abnormal
Days 30-44 eye Ab3-gnat1 labeling decreased amount, abnormal
Days 30-44 eye rp2 expression decreased amount, abnormal
Days 45-89 eye ab1-grk1 labeling decreased amount, abnormal
Days 45-89 eye Ab3-gnat1 labeling decreased amount, abnormal
Days 45-89 eye pde6b expression decreased amount, abnormal
Days 45-89 eye rp2 expression decreased amount, abnormal
rp2hzu2/hzu2 standard conditions Days 30-44 eye rp2 expression decreased amount, abnormal
Days 30-44 eye pde6b expression decreased amount, abnormal
Days 30-44 eye Ab3-gnat1 labeling decreased amount, abnormal
Days 30-44 eye ab1-grk1 labeling decreased amount, abnormal
Days 45-89 eye ab1-grk1 labeling decreased amount, abnormal
Days 45-89 eye rp2 expression decreased amount, abnormal
Days 45-89 eye pde6b expression decreased amount, abnormal
Days 45-89 eye Ab3-gnat1 labeling decreased amount, abnormal
Adult photoreceptor outer segment layer ab5-rho labeling decreased distribution, abnormal
Adult photoreceptor outer segment layer decreased thickness, abnormal
Adult photoreceptor outer segment layer photoreceptor outer segment shortened, abnormal
Full text @ J. Biol. Chem.