ZFIN ID: ZDB-FIG-170223-10
Asad et al., 2016 - Rescue of neural crest derived phenotypes in a zebrafish CHARGE model by sox10 downregulation. Hum. Mol. Genet.   25(16):3539-3554 Full text @ Hum. Mol. Genet.
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Genes:
Fish:
Knockdown Reagents:
Anatomical Terms:
Stage: Prim-5
PHENOTYPE:
Fish:
Knockdown Reagents:
Observed In:
Stage Range: Prim-5 to Day 5

Fig. 4 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression Details
Gene Antibody Fish Conditions Stage Qualifier Anatomy Assay
dct TU control Prim-5 melanocyte ISH
TU + MO1-sox10 standard conditions Prim-5 melanocyte ISH
TU + MO1-sox10 + MO8-chd7 standard conditions Prim-5 melanocyte ISH
TU + MO8-chd7 standard conditions Prim-5 melanocyte ISH
GFP w47Tg control Prim-5 head melanoblast IFL
Prim-5 neural crest melanoblast IFL
w47Tg + MO8-chd7 control Prim-5 head melanoblast IFL
Prim-5 neural crest melanoblast IFL
mitfa TU control Prim-5 head melanoblast ISH
Prim-5 neural crest melanoblast ISH
TU + MO1-sox10 standard conditions Prim-5 Not Detected whole organism ISH
TU + MO1-sox10 + MO8-chd7 standard conditions Prim-5 head melanoblast ISH
Prim-5 neural crest melanoblast ISH
TU + MO8-chd7 standard conditions Prim-5 head melanoblast ISH
Prim-5 neural crest melanoblast ISH
tyr TU control Prim-5 melanocyte ISH
TU + MO1-sox10 standard conditions Prim-5 Not Detected whole organism ISH
TU + MO1-sox10 + MO8-chd7 standard conditions Prim-5 melanocyte ISH
TU + MO8-chd7 standard conditions Prim-5 melanocyte ISH
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
TU + MO1-sox10 standard conditions Prim-5 melanocyte dct expression decreased amount, abnormal
Prim-5 whole organism tyr expression absent, abnormal
Prim-5 whole organism mitfa expression absent, abnormal
TU + MO1-sox10 + MO8-chd7 standard conditions Prim-5 head melanoblast mitfa expression decreased amount, abnormal
Prim-5 melanocyte dct expression decreased amount, abnormal
Prim-5 melanocyte tyr expression decreased amount, abnormal
Prim-5 neural crest melanoblast mitfa expression decreased amount, abnormal
TU + MO8-chd7 standard conditions Prim-5 melanocyte tyr expression decreased amount, abnormal
Prim-5 melanocyte dct expression decreased amount, abnormal
Prim-5 neural crest melanoblast mitfa expression increased amount, abnormal
Long-pec whole organism decreased pigmentation, abnormal
Long-pec whole organism Melanin decreased amount, abnormal
Day 5 eye iridophore absent, abnormal
Day 5 trunk iridophore absent, abnormal
Day 5 whole organism decreased pigmentation, abnormal
Day 5 whole organism Melanin decreased amount, abnormal
Day 5 whole organism melanocyte shape, abnormal
w47Tg + MO8-chd7 control Prim-5 head melanoblast GFP expression increased amount, abnormal
Prim-5 neural crest melanoblast GFP expression increased amount, abnormal
Full text @ Hum. Mol. Genet.