ZFIN Figure: Wu et al., 2015, Fig. 1

ZFIN ID: ZDB-FIG-160328-86

ZFIN ID: ZDB-FIG-160328-86

Wu et al., 2015 - Talin1 is required for cardiac Z-disk stabilization and endothelial integrity in zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 29(12):4989-5005 Full text @ FASEB J.

ADDITIONAL FIGURES

EXPRESSION / LABELING:

Genes:	DsRed2 GFP
Fish:	la116Tg f1Tg; la116Tg la116Tg ; tln1^f102k/f102k tln1^f102k/f102k ; f2Tg ; la116Tg
Anatomical Terms:	endocardium intersegmental vessel myocardium nucleus
Stage Range:	Prim-25 to Long-pec

PHENOTYPE:

Fish:	tln1^f102k/f102k la116Tg ; tln1^f102k/f102k tln1^f102k/f102k ; f2Tg ; la116Tg
Observed In:	blood circulation blood vasculature brain cardiac muscle cell cardiac muscle cell apoptotic process cardiac muscle cell proliferation dorsal aorta heart heart contraction intersegmental vessel posterior cardinal vein
Stage Range:	Prim-25 to Long-pec

Fig. 1 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression Details

Gene	Fish	Conditions	Stage	Anatomy	Assay
DsRed2	f1Tg; la116Tg	standard conditions	Long-pec	myocardium nucleus	IFL
	tln1^f102k/f102k ; f2Tg ; la116Tg	standard conditions	Long-pec	myocardium nucleus	IFL
GFP	f1Tg; la116Tg	standard conditions	Long-pec	endocardium	IFL
	la116Tg	standard conditions	Prim-25	intersegmental vessel	IFL
			Long-pec	intersegmental vessel	IFL
	la116Tg ; tln1^f102k/f102k	standard conditions	Prim-25	intersegmental vessel	IFL
			Long-pec	intersegmental vessel	IFL
	tln1^f102k/f102k ; f2Tg ; la116Tg	standard conditions	Long-pec	endocardium	IFL

Antibody Labeling Details No data available

Phenotype Details

Fish	Conditions	Stage	Phenotype
la116Tg ; tln1^f102k/f102k	standard conditions	Long-pec	dorsal aorta decreased diameter, abnormal
		Long-pec	intersegmental vessel GFP expression decreased amount, abnormal
		Long-pec	posterior cardinal vein decreased diameter, abnormal
tln1^f102k/f102k	standard conditions	Prim-25	blood circulation process quality, normal
		Prim-25	blood vasculature spatial pattern, normal
		Long-pec	brain hemorrhagic, abnormal
		Long-pec	cardiac muscle cell apoptotic process process quality, normal
		Long-pec	cardiac muscle cell decreased amount, abnormal
		Long-pec	cardiac muscle cell decreased size, abnormal
		Long-pec	cardiac muscle cell proliferation decreased process quality, abnormal
		Long-pec	heart contraction decreased efficiency, abnormal
		Long-pec	heart contraction decreased frequency, abnormal
		Long-pec	heart decreased volume, abnormal
tln1^f102k/f102k ; f2Tg ; la116Tg	standard conditions	Long-pec	heart contraction decreased frequency, abnormal
		Long-pec	heart decreased volume, abnormal

Full text @ FASEB J.