ZFIN ID: ZDB-FIG-150528-25
Beck et al., 2014 - Mutation of POC1B in a Severe Syndromic Retinal Ciliopathy. Human Mutation   35(10):1153-62 Full text @ Hum. Mutat.
PHENOTYPE:
Fish: AB/TU + MO1-poc1b, AB/TU + MO2-poc1b
Knockdown Reagents: MO1-poc1b, MO2-poc1b
Observed In: cilium assembly, eye, head, kidney, melanocyte (all 15) expand
Stage Range: Day 4 to Day 5

Fig. 5 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression DetailsNo data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
AB/TU + MO1-poc1b standard conditions Day 4 cilium assembly process quality, abnormal
Day 4 pronephros cystic, abnormal
Day 4 retina photoreceptor connecting cilium decreased amount, abnormal
Day 4 retina photoreceptor connecting cilium decreased length, abnormal
Day 4 retinal cone cell decreased length, abnormal
Day 4 retinal cone cell photoreceptor outer segment aplastic/hypoplastic, abnormal
Day 5 eye decreased size, abnormal
Day 5 head decreased size, abnormal
Day 5 kidney cystic, abnormal
Day 5 melanocyte spatial pattern, abnormal
Day 5 pericardium edematous, abnormal
Day 5 retina cell death increased occurrence, abnormal
Day 5 retinal inner nuclear layer cell death increased occurrence, abnormal
Day 5 swim bladder uninflated, abnormal
Day 5 whole organism viability, abnormal
Day 5 whole organism anterior-posterior axis curved ventral, abnormal
Day 5 whole organism anterior-posterior axis decreased length, abnormal
AB/TU + MO2-poc1b standard conditions Day 4 cilium assembly process quality, abnormal
Day 4 pronephros cystic, abnormal
Day 4 retina photoreceptor connecting cilium decreased amount, abnormal
Day 4 retina photoreceptor connecting cilium decreased length, abnormal
Day 4 retinal cone cell decreased length, abnormal
Day 4 retinal cone cell photoreceptor outer segment aplastic/hypoplastic, abnormal
Day 5 eye decreased size, abnormal
Day 5 head decreased size, abnormal
Day 5 kidney cystic, abnormal
Day 5 melanocyte spatial pattern, abnormal
Day 5 pericardium edematous, abnormal
Day 5 retina cell death increased occurrence, abnormal
Day 5 retinal inner nuclear layer cell death increased occurrence, abnormal
Day 5 swim bladder uninflated, abnormal
Day 5 whole organism viability, abnormal
Day 5 whole organism anterior-posterior axis curved ventral, abnormal
Day 5 whole organism anterior-posterior axis decreased length, abnormal
Full text @ Hum. Mutat.