FIGURE

Fig. 4

ID
ZDB-FIG-150428-4
Publication
Yang et al., 2015 - CNS Myelination Requires Cytoplasmic Dynein Function
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Fig. 4

Axon wrapping by oligodendrocyte membrane is abnormal in dync1h1vu76 mutant larvae. Panels show images captured from time-lapse movies of oligodendrocytes marked by Tg(nkx2.2:EGFP-CaaX) reporter expression beginning at 2.5 dpf. Time elapsed since beginning of movies is marked on the left. Images were obtained from lateral view of the trunk spinal cord, with dorsal up. A: In wild-type larvae, oligodendrocyte membrane processes contact axons, initiate tight wrapping and lengthen bi-directionally to form myelin sheaths (see example sheaths 1 and 2). Once formed, most sheaths are stable and rarely lost. B: In dync1h1vu76 mutant larvae, some sheaths do not lengthen (e.g., sheath 3) and some shorten and are subsequently lost (e.g., sheath 4). Sheath 5 forms a relatively long segment.

Expression Data
Gene:
Fish:
Anatomical Terms:
Stage: Pec-fin

Expression Detail
Antibody Labeling
Phenotype Data
Fish:
Observed In:
Stage: Pec-fin

Phenotype Detail
Acknowledgments
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