|ZFIN ID: ZDB-FIG-150313-24|
Inhibition of FGFRs Results in Reduced VE-Cadherin Junctions
Immunostaining of whole-mount zebrafish embryos for VE-cadherin (A and D, or red in C and F), showing intact and continuous EC-cell contacts in control-treated Tg(fli1:EGFP)y1 zebrafish embryos at 49 hpf (A–C), while SSR-treated zebrafish (exposure to 75 μM in the swimming water; tissue concentration 2.4 μg SSR/mg protein) (D–F) had a discontinuous VE-cadherin lining with reduced VE-cadherin-positive EC-cell juctions, explaining why ECs became disconnected from each other.
|y1Tg||chemical treatment: pharmaceutical||Long-pec||intersegmental vessel||IHC|
|IHC||y1Tg||chemical treatment: pharmaceutical||Long-pec|
|y1Tg||chemical treatment: pharmaceutical||Long-pec||blood vessel endothelial cell cell-cell junction decreased amount, abnormal|
|Long-pec||intersegmental vessel endothelial cell decreased adhesivity, abnormal|
|Acknowledgments:||ZFIN wishes to thank the journal Chemistry & Biology for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Chem. Biol.|