ZFIN ID: ZDB-FIG-140425-12
Han et al., 2014 - The Nogo-C2/Nogo receptor complex regulates the morphogenesis of zebrafish lateral line primordium through modulating the expression of dkk1b, a Wnt signal inhibitor. PLoS One   9(1):e86345 Full text @ PLoS One
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Knockdown Reagents:
Observed In:
Stage: Protruding-mouth

Fig. 3

Defects in neuromast formation were observed in both Rtn4-m/Nogo-C2 and NgRH1a morphants.

Zebrafish embryos were injected with morpholinos against the indicated zebrafish Nogo-related ligand or Nogo receptor at the 2~4-cell stage. Neuromast formation in these morphants was observed by staining with 4-Di-2-ASP at 72 h post-fertilization (hpf). A control embryo is shown in panel (A). Images were taken from the lateral view, and the yellow dots indicate neuromasts of the zebrafish lateral line. Scale bar, 100 μm. A summary of PLL neuromast numbers in MO-injected embryo is shown in panel (I). Sample size (N) and MO dosage used are indicated.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
WT + MO1-rtn4rl2a standard conditions Protruding-mouth posterior lateral line neuromast decreased amount, abnormal
WT + MO7-rtn4a standard conditions Protruding-mouth posterior lateral line neuromast decreased amount, abnormal
Acknowledgments:
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS One