ZFIN ID: ZDB-FIG-131107-4
Neal et al., 2013 - H. pylori Virulence Factor CagA Increases Intestinal Cell Proliferation by Wnt Pathway Activation in a Transgenic Zebrafish Model. Disease models & mechanisms   6(3):802-10 Full text @ Dis. Model. Mech.
ADDITIONAL FIGURES
PHENOTYPE:
Fish: tcf7l2zf55/zf55, b1232Tg, tcf7l2zf55/zf55; b1232Tg
Observed In: epithelial cell proliferation, intestinal epithelial cell
Stage: Days 14-20

Fig. 4

CagA-dependent overproliferation of the intestinal epithelium requires tcf4. Intestinal epithelial cell proliferation at 15 dpf. Bars represent proliferation (mean ± s.e.m.) as a percentage of wild-type; n=10, *P<0.05 using one-way ANOVA with Tukey’s test.

Gene Expression DetailsNo data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
b1232Tg standard conditions Days 14-20 epithelial cell proliferation increased occurrence, abnormal
Days 14-20 intestinal epithelial cell proliferative, abnormal
tcf7l2zf55/zf55 standard conditions Days 14-20 epithelial cell proliferation process quality, normal
Days 14-20 intestinal epithelial cell proliferative, normal
tcf7l2zf55/zf55; b1232Tg standard conditions Days 14-20 epithelial cell proliferation process quality, normal
Days 14-20 intestinal epithelial cell proliferative, normal
Acknowledgments:
ZFIN wishes to thank the journal Disease models & mechanisms for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Dis. Model. Mech.