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ZFIN ID: ZDB-FIG-121101-14
Weiss et al., 2012 - Abnormal vasculature interferes with optic fissure closure in lmo2 mutant zebrafish embryos. Developmental Biology   369(2):191-198 Full text @ Dev. Biol.
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Genes:
Fish:
Anatomical Terms:
Stage: Long-pec
PHENOTYPE:
Fish:
Observed In:
Stage: Long-pec

Fig. 5 Dilated vessels are located in the optic fissure. (A–F) Three-dimensional shadow rendering of confocal z-stacks of eyes (green) and ocular vessels (red) in 2 dpf (rx3:Gal4-VP16);(UAS:EGFP);(kdrl:HsHRAS-mCherry) transgenic normal (A–C) and lmo2vu270/vu270 (D–F) embryos. In the merged panels (C and F) most of the hyaloid vessels cannot be seen. (E and F) Growth of superficial ring vessel is delayed in the mutant (compare to B and C). Arrows point at the optic fissure. Inset in F is a higher magnification of the optic fissure area with the arrow pointing at the dilated vessel in the fissure. Vessel abbreviations are as in Fig. 2. All panels are dorsolateral view, anterior to the left.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
EGFP lmo2vu270/vu270; s896Tg; vu157Tg; vu271Tg standard conditions Long-pec lens IHC
Long-pec retina IHC
s896Tg; vu157Tg; vu271Tg standard conditions Long-pec lens IHC
Long-pec retina IHC
mCherry lmo2vu270/vu270; s896Tg; vu157Tg; vu271Tg standard conditions Long-pec ocular blood vessel blood vessel endothelium IHC
s896Tg; vu157Tg; vu271Tg standard conditions Long-pec ocular blood vessel blood vessel endothelium IHC
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
lmo2vu270/vu270; s896Tg; vu157Tg; vu271Tg standard conditions Long-pec embryonic retina morphogenesis in camera-type eye delayed, abnormal
Long-pec ocular blood vessel dilated, abnormal
Long-pec optic fissure increased width, abnormal
Long-pec retinal blood vessel morphogenesis decreased process quality, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Developmental Biology for permission to reproduce figures from this article. Please note that this material may be protected by copyright.

Reprinted from Developmental Biology, 369(2), Weiss, O., Kaufman, R., Michaeli, N., and Inbal, A., Abnormal vasculature interferes with optic fissure closure in lmo2 mutant zebrafish embryos, 191-198, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.