Fig. 7
- ID
- ZDB-FIG-121026-31
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- Tanaka et al., 2012 - Dpysl2 (CRMP2) and Dpysl3 (CRMP4) phosphorylation by Cdk5 and DYRK2 is required for proper positioning of Rohon-Beard neurons and neural crest cells during neurulation in zebrafish
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The position of Rohon-Beard neurons was specifically affected by loss of function of cdk5, dyrk2, dpysl2 and dpysl3. (A–L) The transverse views of the spinal cord in the wild-type embryos (A–D), the cdk5 and dyrk2 double morphants (E–H) and the dpysl2 and dpysl3 double morphants (I–L) at 28 hpf, dorsal top. Red arrowheads indicate RB neurons, blue arrows indicate interneurons and white allows indicate primary motor neurons. Broken lines indicate margin of spinal cord. In the wild-type embryos, CREST2:GFP-labeled RB neurons and interneurons (A, B), and SV2-labeled primary motor neurons (A, C) were located bilaterally. However, in the cdk5 and dyrk2 double morphants or the dpysl2 and dpysl3 double morphanst, RB neuron was observed on the midline while other types of neurons were located normally like the wild-type embryos (E–G, I–K). |
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| Stage: | Prim-5 |
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| Stage: | Prim-5 |
Reprinted from Developmental Biology, 370(2), Tanaka, H., Morimura, R., and Ohshima, T., Dpysl2 (CRMP2) and Dpysl3 (CRMP4) phosphorylation by Cdk5 and DYRK2 is required for proper positioning of Rohon-Beard neurons and neural crest cells during neurulation in zebrafish, 223-236, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.