FIGURE

Fig. 8

ID

ZDB-FIG-120131-50

Publication

Du et al., 2012 - Differential regulation of epiboly initiation and progression by zebrafish Eomesodermin A

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Fig. 8

Expression of endoderm markers is reduced in MZeomesa embryos. (A-C′, G, G′, I-J′) lateral views, (D-F′, H, H′, K-M′) animal pole views of embryos stained by whole mount in situ hybridzation. (A-B′) mxtx2 expression at sphere (A-A′′) and dome stage. (B′) gsc in red marks dorsal. (C-D′′) ndr1 expression at sphere (arrow, C,C′) and 40% epiboly (D-D′′). (E, E′) ndr2 expression at 40% epiboly. (F,F′) lft1 expression at 40% epiboly (G-H′) sox32 expression at 40% epiboly, (H′) gsc in red marks dorsal. sox32 expression (I,I′) and sox17 expression (J,J′) at 75% epiboly. Arrowheads indicate dorsal forerunner cells. (K-K′′) gata5 expression at 40% epiboly. (L,L′) bon expression at 40% epiboly (M,M′) og9x expression at 40% epiboly. (N.N′) pou5f1 at oblong/sphere. Genotypes indicated in lower left, probe in upper right and percentages of embryos that exhibited given phenotype shown in lower right where appropriate.

Expression Data

Genes:	gata5 lft1 mixl1 mxtx2 ndr1 ndr2 pou5f3 sebox sox17 sox32
Fish:	AB eomesa^fh105/fh105 (AB)
Anatomical Terms:	blastodisc blastodisc lateral margin forerunner cell group hypoblast endodermal cell margin margin dorsal region yolk syncytial layer yolk syncytial layer dorsal region
Stage Range:	Sphere to 75%-epiboly

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	eomesa^fh105/fh105 (AB)
Observed In:	endodermal cell fate specification forerunner cell group
Stage:	75%-epiboly

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 362(1), Du, S., Draper, B.W., Mione, M., Moens, C.B., and Bruce, A.E., Differential regulation of epiboly initiation and progression by zebrafish Eomesodermin A, 11-23, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.