FIGURE

Fig. 2

ID

ZDB-FIG-111220-4

Publication

Doll et al., 2011 - Subnuclear development of the zebrafish habenular nuclei requires ER translocon function

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Fig. 2

Kctd12.1 expression is significantly expanded and Kctd12.2 expression significantly decreased throughout larval development in c163 mutants. (A, B, C) In wild-type larvae at 48 hpf, there are 2.1 times as many Kctd12.1-expressing neurons (green) in the left LsDh of the dorsal habenula as in the right. In the MsDh, there are 1.3 times as many Kctd12.2-expressing neurons (red) in the right side as the left. (A′, B′, C′) In c163 mutants, more Kctd12.1+ and fewer Kctd12.2+ neurons are found in the right habenula. (D–F′) At 72 hpf, a similar situation to 48 hpf is observed. Images are 3D reconstructions of 50 μm-thick confocal Z-stacks through the epithalamus. Scale bars represent 10 μm. Significance determined by Student′s T-test (*p < 0.05, **p < 0.01); n > 6. Insets in A–B′, D–E′ show ToPro3 labeling in a single confocal section of the Z-stack.

Expression Data

Genes:	kctd12.1 kctd12.2
Fish:	AB sec61a1a^c163/c163 (AB)
Anatomical Terms:	dorsal habenular nucleus lateral region dorsal habenular nucleus medial region
Stage Range:	Long-pec to Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	sec61a1a^c163/c163 (AB)
Observed In:	dorsal habenular nucleus lateral region dorsal habenular nucleus medial region dorsal habenular nucleus neuron dorsal habenular nucleus right side neuron
Stage Range:	Long-pec to Protruding-mouth

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 360(1), Doll, C.A., Burkart, J.T., Hope, K.D., Halpern, M.E., and Gamse, J.T., Subnuclear development of the zebrafish habenular nuclei requires ER translocon function, 44-57, Copyright (2011) with permission from Elsevier. Full text @ Dev. Biol.