ZFIN ID: ZDB-FIG-101004-27
Kelsh et al., 1996 - Zebrafish pigmentation mutations and the processes of neural crest development. Development (Cambridge, England)   123:369-389 Full text @ Development
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Observed In:
Stage Range: Prim-5 to Day 6

Fig. 5 Phenotypes of ectopic chromatophore mutations (Class V). Wild-type siblings are compared with homozygous mutants for mon (A-D), pde (E,H-K) and flh (F,G). mon larvae display on the sixth day large numbers of iridophores extending into the medial fins (C,D), while medial fins (blue outline) are irregular in shape and reduced in area (D). During the pharyngula period, melanophores are normally found in close association with the neural tube in a dorsal position (F), but in flh mutant embryos they completely encircle the neural tube (melanophores on the ventral surface of the tube; arrow, G). On the sixth day, pde larvae show dorsoventrally oriented chromatophores ventral to the notochord and dorsal to the ventral stripe (H, and at higher magnification, in I), which are not present in the wild type (E). Most of these chromatophores look like melanophores under transmitted light, but have large regions (see arrowhead, I) with the appearance of iridophores. When viewed with incident light (J,K), most of these chromatophores (e.g. long arrow, K) look like iridophores. The morphology of these regions strongly implies that the same cell contains both melanosomes and iridosomes. Some of these chromatophores (short arrow, I and K) appear to be pure iridophores. B-D and I-K were photographed with incident light. nt, neural tube. Scale bars, 200 μm (A,C), 400 μm (B,D), 225 μm (E,H,J), 70 μm (F,G) and 110 μm (I,K).

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
ednraatj262/tj262 standard conditions Day 6 iridophore spatial pattern, abnormal
Day 6 melanocyte mislocalised, abnormal
Day 6 post-vent region ventro-lateral region increased accumulation iridophore, abnormal
Day 6 post-vent region ventro-lateral region increased accumulation melanocyte, abnormal
Day 6 trunk ventro-lateral region increased accumulation iridophore, abnormal
Day 6 trunk ventro-lateral region increased accumulation melanocyte, abnormal
ednraatv212/tv212 standard conditions Day 6 iridophore spatial pattern, abnormal
Day 6 melanocyte mislocalised, abnormal
Day 6 post-vent region ventro-lateral region increased accumulation iridophore, abnormal
Day 6 post-vent region ventro-lateral region increased accumulation melanocyte, abnormal
Day 6 trunk ventro-lateral region increased accumulation iridophore, abnormal
Day 6 trunk ventro-lateral region increased accumulation melanocyte, abnormal
nototk241/tk241 standard conditions Prim-5 melanocyte displaced to neural tube ventral surface, abnormal
nototm229/tm229 standard conditions Prim-5 melanocyte displaced to neural tube ventral surface, abnormal
trim33tb222b/tb222b standard conditions Day 6 dorsal larval melanophore stripe has extra parts of type iridophore, abnormal
Day 6 iridophore displaced to median fin, abnormal
Day 6 median fin decreased area, abnormal
Day 6 median fin shape, abnormal
Day 6 post-vent region ventral larval melanophore stripe has extra parts of type iridophore, abnormal
Day 6 yolk larval melanophore stripe has extra parts of type iridophore, abnormal
Acknowledgments:
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Development