FIGURE

Fig. 1

ID

ZDB-FIG-100304-21

Publication

Brown et al., 2010 - Nlcam modulates midline convergence during anterior neural plate morphogenesis

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Fig. 1

nlcam is specifically upregulated in the Rx3/chk mutant. Whole mount in situ expression patterns of CAMs in wild type (A, C, E, G, I, K) and chk mutant (B, D, F, H, J, L) embryos at the 6S (A, B, E–L) or Bud (C, D) stage. Dorsal views, anterior to the left. (A, B) nlcam, 6SS. Insets show cross sections through the anterior neural plate (dorsal is up), showing upregulation of nlcam in the chk presumptive eye field. (C, D) nlcam, Bud stage. nlcam is upregulated in chk at this stage, shortly after the onset of Rx3 expression (domain marked by white stippled line). No other CAMs tested show changes in expression pattern. E, F: ncam. G, H: alcam. I, J: N-cadherin. K, L: E-cadherin. Sections for ncam and N-cadherin, which are expressed in the eye field, are also shown. For alcam and E-cadherin, where there is no or very little expression in the eye, the Rx3 expression domain is marked by the white stippled line.

Expression Data

Genes:	alcama alcamb cdh1 cdh2 ncam1a
Fish:	WIK/AB rx3^s399/s399
Anatomical Terms:	anterior neural plate anterior neural rod
Stage Range:	Bud to 5-9 somites

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	rx3^s399/s399
Observed In:	optic primordium optic vesicle morphogenesis
Stage Range:	Bud to 5-9 somites

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 339(1), Brown, K.E., Keller, P.J., Ramialison, M., Rembold, M., Stelzer, E.H., Loosli, F., and Wittbrodt, J., Nlcam modulates midline convergence during anterior neural plate morphogenesis, 14-25, Copyright (2010) with permission from Elsevier. Full text @ Dev. Biol.