FIGURE

Fig. 4

ID
ZDB-FIG-090710-44
Publication
Lightcap et al., 2009 - Interaction with LC8 is required for Pak1 nuclear import and is indispensable for zebrafish development
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Fig. 4

Pak1 nuclear import is critical for zebrafish development and survival.

(A) Representative images of zebrafish embryos at 4 dpf. Embyros were co-injected with the morpholino (MO1) and either human wt-Pak1 mRNA, human Pak1-NLSmut or human Pak1-LC8mut (last three panels). Uninjected embryos and MO1 only injected embryos are also shown. (B–D) Quantitative analysis of differential zebrafish survival, body length, and extent of cardiac edema at 4 dpf in embryos injected with different morpholino/Pak1 mRNA combinations. For B, percent survival of uninjected control fish is approximately 90%. For D, cardiac edema for experimental fish was normalized to the control fish.

Expression Data

Expression Detail
Antibody Labeling
Phenotype Data
Fish:
Knockdown Reagent:
Observed In:
Stage: Day 4

Phenotype Detail
Acknowledgments
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