ZFIN ID: ZDB-FIG-090224-37
Hammond et al., 2009 - A late role for bmp2b in the morphogenesis of semicircular canal ducts in the zebrafish inner ear. PLoS One   4(2):e4368 Full text @ PLoS One
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Condition:
Observed In:
Stage: Adult

Fig. 1 Semicircular canal ducts are absent, but sensory patches are present, in the inner ears of adult rescued swr zebrafish.

(A–F) 10 μm resin parasagittal sections through the inner ears of adult rescued swr zebrafish and age-matched wild-types (anterior to the left, dorsal to the top). Note the absence of semicircular canal ducts in the rescued swr ear (A), which are clearly present in the wild-type ear in an equivalent section (B, showing lumens of anterior and posterior canal ducts). All sensory patches detected in the wild-type ears are also present in the rescued swr ears. Differences in the orientation of the lagenar macula (E, F) reflect a slight difference in the position of the wild-type and swr sections for this pair of panels. (G–J) Higher magnification views of the posterior crista (G, H) and utricular macula (I, J). The structure of the sensory patches is similar in both rescued swr and wild-type ears. Abbreviations: ac, anterior crista; lc, lateral crista; pc, posterior crista; ascc, anterior semicircular canal duct; lscc, lateral semicircular canal duct; cc, crus commune; ut, utricular macula; s, saccular macula; lg, lagenar macula; br, brain; s, somite; gl, gill. Scale bar, (A–F) 400 μm; (G–J) 50 μm.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
bmp2bta72a/ta72a chemical treatment: messenger RNA Adult anterior crista morphology, normal
Adult lagena morphology, normal
Adult lateral crista morphology, normal
Adult macula saccule morphology, normal
Adult macula utricle morphology, normal
Adult posterior crista morphology, normal
Adult saccule morphology, normal
Adult semicircular canal malformed, abnormal
Adult semicircular canal morphogenesis process quality, abnormal
Adult utricle morphology, normal
bmp2btc300a/tc300a chemical treatment: messenger RNA Adult anterior crista morphology, normal
Adult lagena morphology, normal
Adult lateral crista morphology, normal
Adult macula saccule morphology, normal
Adult macula utricle morphology, normal
Adult posterior crista morphology, normal
Adult saccule morphology, normal
Adult semicircular canal malformed, abnormal
Adult semicircular canal morphogenesis process quality, abnormal
Adult utricle morphology, normal
bmp2btdc24/tdc24 chemical treatment: messenger RNA Adult anterior crista morphology, normal
Adult detection of mechanical stimulus involved in equilibrioception process quality, abnormal
Adult lagena morphology, normal
Adult lateral crista morphology, normal
Adult macula saccule morphology, normal
Adult macula utricle morphology, normal
Adult posterior crista morphology, normal
Adult saccule morphology, normal
Adult semicircular canal malformed, abnormal
Adult semicircular canal morphogenesis process quality, abnormal
Adult utricle morphology, normal
Acknowledgments:
ZFIN wishes to thank the journal PLoS One for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ PLoS One