ZFIN ID: ZDB-FIG-081003-22
Yoshida et al., 2008 - Zebrafish orthologue of mental retardation protein IL1RAPL1 regulates presynaptic differentiation. Molecular and cellular neurosciences   39(2):218-228 Full text @ Mol. Cell Neurosci.
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Knockdown Reagent:
Observed In:
Stage: Pec-fin

Fig. 3 Effect of il1rapl1b-MO on the VAMP2-EGFP punctum formation in axon terminals of olfactory sensory neurons. (A) Representative VAMP2-EGFP signals in olfactory neuron axon terminals of embryos injected with Pomp-VG and control-MO (left), Pomp-VG and il1rapl1b-MO (middle) and Pomp-VG-Il1rapl1b and il1rapl1b-MO (right) at 60 hpf. The threshold images of VAMP2-EGFP signals are on the bottom. Arrowheads point axonal shafts. Bar = 5 μm. (B) The area of VAMP2-EGFP puncta in axon terminals of olfactory sensory neurons of embryos injected with Pomp-VG and control-MO (open bar), Pomp-VG and il1rapl1b-MO (filled bar) and Pomp-VG-Il1rapl1b and il1rapl1b-MO (gray bar) at 60 hpf. n = 56–60 for 31–33 embryos. One-way ANOVA: F = 33.9 and p < 0.001. All values represent mean ± SEM. * and ***, p < 0.05 and< 0.001, respectively.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
AB + MO1-il1rapl1b standard conditions Pec-fin olfactory receptor cell synaptic vesicle decreased amount, abnormal
Acknowledgments:
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Reprinted from Molecular and cellular neurosciences, 39(2), Yoshida, T., and Mishina, M., Zebrafish orthologue of mental retardation protein IL1RAPL1 regulates presynaptic differentiation, 218-228, Copyright (2008) with permission from Elsevier. Full text @ Mol. Cell Neurosci.