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ZFIN ID: ZDB-FIG-080904-62
Liu et al., 2008 - Fli1 Acts at the Top of the Transcriptional Network Driving Blood and Endothelial Development. Current biology : CB   18(16):1234-1240 Full text @ Curr. Biol.
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Genes:
Fish:
Knockdown Reagents:
Anatomical Term:
Stage: 10-13 somites
PHENOTYPE:
Fish:
Knockdown Reagents:
Observed In:
Stage: 10-13 somites

Fig. 4 Fli1 May Act in Parallel with Cloche but Upstream of Scl and Etsrp

(A–J) WISH on wild-type or Cloche mutant zebrafish embryos injected with combinations of Fli1-VP16 mRNA and/or Scl/Etsrp MOs. 10 s stage, dorsal view, head to top.

(K) A genetic regulatory network linking Bmp to Fli1 at the top of the hemangioblast hierarchy, drawn according to Davidson et al. [29]. Solid lines, direct regulation; dashed lines, no evidence for direct or indirect. Evidence for links quoted in text, apart from Gata2 as a direct Bmp target [32].

Gene Expression Details
Gene Antibody Fish Conditions Stage Qualifier Anatomy Assay
kdrl AB control 10-13 somites posterior lateral mesoderm ISH
AB + MO2-etv2 standard conditions 10-13 somites posterior lateral mesoderm ISH
AB + MO4-tal1 standard conditions 10-13 somites posterior lateral mesoderm ISH
tal1 AB standard conditions 10-13 somites posterior lateral mesoderm ISH
npas4ls5/s5 standard conditions 10-13 somites Not Detected posterior lateral mesoderm ISH
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
AB + MO2-etv2 standard conditions 10-13 somites embryonic hemopoiesis disrupted, abnormal
10-13 somites posterior lateral mesoderm morphology, abnormal
AB + MO4-tal1 standard conditions 10-13 somites embryonic hemopoiesis disrupted, abnormal
10-13 somites posterior lateral mesoderm morphology, abnormal
npas4ls5/s5 standard conditions 10-13 somites embryonic hemopoiesis disrupted, abnormal
10-13 somites posterior lateral mesoderm morphology, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Current biology : CB for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Curr. Biol.