ZFIN ID: ZDB-FIG-070219-14
Hernandez et al., 2007 - Cyp26 enzymes generate the retinoic acid response pattern necessary for hindbrain development. Development (Cambridge, England)   134(1):177-187 Full text @ Development
ADDITIONAL FIGURES
EXPRESSION / LABELING:
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Anatomical Terms:
Stage: 5-9 somites

Fig. 5 Exogenous RA disrupts cyp26b1 and cyp26c1 expression in cyp26a1-/- embryos but not in wild type. cyp26b1 (A-D) and cyp26c1 (E-H) expression (blue) is established normally in wild-type (A,E) and cyp26a1-/- (B,F) embryos at the 6-somite stage (12 hpf). cyp26b1 and cyp26c1 expression is also established normally in wild-type embryos treated with a sub-teratogenic concentration of RA (5 nM; C,G), but not in cyp26a1-/- embryos treated with 5 nM RA (D,H). krox20 expression is shown in red.

Gene Expression Details
Gene Antibody Fish Conditions Stage Qualifier Anatomy Assay
cyp26b1 cyp26a1rw716/rw716 control 5-9 somites presumptive rhombomere 3 ISH
5-9 somites presumptive rhombomere 4 ISH
cyp26a1rw716/rw716 chemical treatment: all-trans-retinoic acid 5-9 somites Not Detected neural rod ISH
cyp26c1 cyp26a1rw716/rw716 control 5-9 somites presumptive rhombomere 2 ISH
5-9 somites presumptive rhombomere 3 ISH
5-9 somites presumptive rhombomere 4 ISH
5-9 somites presumptive rhombomere 5 ISH
5-9 somites presumptive rhombomere 6 ISH
cyp26a1rw716/rw716 chemical treatment: all-trans-retinoic acid 5-9 somites Not Detected neural rod ISH
egr2b cyp26a1rw716/rw716 control 5-9 somites presumptive rhombomere 3 ISH
5-9 somites presumptive rhombomere 5 ISH
cyp26a1rw716/rw716 chemical treatment: all-trans-retinoic acid 5-9 somites Not Detected neural rod ISH
Antibody Labeling Details No data available
Phenotype Details No data available
Acknowledgments:
ZFIN wishes to thank the journal Development (Cambridge, England) for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Development